Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00677768 · ClinicalTrials.gov registry record
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
A clinical trial, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- 475
- Enrollment target
NCT00677768: Completed study, sponsored by Massachusetts General Hospital.
NCT00677768 is a clinical trial that has completed, run by Massachusetts General Hospital. The registered enrollment target is 475 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00677768 has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- 475 participants
- Enrollment target
Study Summary
The purpose of this study is to collect 650 blood and 300 cerebrospinal fluid (CSF) samples from people with amyotrophic lateral sclerosis (ALS), pure lower or upper motor neuron diseases, as well as other neurodegenerative diseases and from people with no neurological disorder. Through comparison of these samples, the researchers hope to learn more about the underlying cause of ALS, as well as find unique biological markers, which could be used to diagnose ALS and monitor disease progression. Additionally, up to 600 blood samples will be collected for a sub-study for DNA analysis. Studying components of the blood, such as DNA, may help us understand what happens when genes function abnormally and how it might be related to disease.
Primary Outcome
The ALSFRS-R is a quickly administered (5 min) ordinal rating scale used to determine a subject's assessment of their capability and independence in 12 functional activities. There are 12 questions, graded by the subject 0-4 (4 is normal). Score of 0 (worst) to 48 (best). Reflects speech and swallowing, fine motor skills, large motor skills, and breathing.
Interventions
- OTHER No intervention
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 475 participants |
| Start Date | 2008-04 |
| Est. Completion | 2015-11 |
What the finished NCT00677768 record still lists
NCT00677768 is an observational study that tracks outcomes without assigning an intervention. The registered 475 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which No intervention is the first listed.
NCT00677768 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00677768 about?
NCT00677768 is a clinical study titled "Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)". The purpose of this study is to collect 650 blood and 300 cerebrospinal fluid (CSF) samples from people with amyotrophic lateral sclerosis (ALS), pure lower or upper motor neuron diseases, as well as other neurodegenerative diseases and from people with no neurological disorder. Through comparison o...
What is the current status of trial NCT00677768?
This trial is currently completed. The enrollment target is 475 participants. The study started on 2008-04. Estimated completion is 2015-11.
What interventions are being tested in trial NCT00677768?
The interventions under investigation include: No intervention (OTHER).
Who is sponsoring clinical trial NCT00677768?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01788839 · 475 participants
Longitudinal Sexual and Reproductive Health Study of Women With Breast Cancer and Lymphoma
- NCT05451303 · 475 participants
Detection of Oral and Throat Cancers Using OralViome Cancer Testing System
- NCT06892379 · 475 participants · Phase 1
A Study of HS-20110 in Participants With Advanced Solid Tumors
- NCT06754046 · 476 participants · NA
BELIEVE Trial: Bulking vErsus sLing for Treating Stress Urinary IncontinEnce at the Time of Vaginal prolapsE Repair (BELIEVE)
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia