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NCT00659490 · ClinicalTrials.gov registry record · Phase 2
Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940
A Phase 2 study, sponsored by AstraZeneca.
- Completed
- Registry status
- Phase 2
- Development phase
- 151
- Enrollment target
NCT00659490: Completed Phase 2 study, sponsored by AstraZeneca.
NCT00659490 is a Phase 2 study that has completed, run by AstraZeneca. The registered enrollment target is 151 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (14% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00659490, a Phase 2 study, has completed, sponsored by AstraZeneca.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 151 participants
- Enrollment target
Study Summary
The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth. This will be done by comparing the effect of AZD1940 to placebo ("inactive substance") on pain. A number of patients will instead receive the common painkiller naproxen for comparison purposes. Rescue medication, acetaminophen, will be allowed if a need for additional painkillers would arise. A number of patients will receive Naproxen as control.
Primary Outcome
Area under the Visual Analogue Scale (VAS, 0-100 mm) time curve 0-8h (from end of surgery). Missing values in the pain-by-time curve was imputated using linear interpolation, last observation carried forward (LOCF) or first observation carried backwards (FOCB) as applicable.
Interventions
- DRUG Placebo
- DRUG Naproxen
- DRUG AZD1940
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 151 participants |
| Start Date | 2008-02 |
| Est. Completion | 2008-05 |
| Phase | Phase 2 |
What the finished NCT00659490 record still lists
NCT00659490 is an interventional study that assigns participants to a tested intervention. The registered 151 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (14% higher).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT00659490 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00659490 about?
NCT00659490 is a clinical study titled "Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940". The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth. This will be done by comparing the effect of AZD1940 to placebo ("inactive substance") on pain. A number of patients will instead receive the common painkiller n...
What is the current status of trial NCT00659490?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 151 participants. The study started on 2008-02. Estimated completion is 2008-05.
What interventions are being tested in trial NCT00659490?
The interventions under investigation include: Placebo (DRUG), Naproxen (DRUG), AZD1940 (DRUG).
Who is sponsoring clinical trial NCT00659490?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00659490's enrollment target sits among peer trials
151 454th of 2000 higher than 1,546 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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