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NCT00659204 · ClinicalTrials.gov registry record · Phase 3
Efficacy of Silver Nanoparticle Gel Versus a Common Antibacterial Hand Gel
A Phase 3 study, sponsored by Madigan Army Medical Center.
- Terminated
- Registry status
- Phase 3
- Development phase
- 22
- Enrollment target
NCT00659204: Clinical Trial Phase 3 study, sponsored by Madigan Army Medical Center.
NCT00659204 is a Phase 3 study that was terminated before completion, run by Madigan Army Medical Center. The registered enrollment target is 22 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00659204, a Phase 3 study, was terminated before completion, sponsored by Madigan Army Medical Center.
- TERMINATED
- Registry status
- Phase 3
- Development phase
- 22 participants
- Enrollment target
Study Summary
The purpose of this pilot study is to compare the antimicrobial efficacy of silver nanoparticle gel to a commercialized alcohol-based hand gel on bacterial counts isolated from the hands of 40 volunteers seeded with Serratia marcescens, a surrogate microbial marker. Specific aims of this study are: Aim #1: Compare the immediate antimicrobial efficacy of a one-time application of silver nanoparticle gel (SilvaSorb , AcryMed, Inc., Portland, OR) versus an alcohol-based hand gel (Purell, GoJo Industries, Akron, OH) in reducing transient bacterial counts isolated from hands seeded with S. marcescens. Aim # 2: Compare the persistent antimicrobial efficacy of a one-time application of silver nanoparticle gel (SilvaSorb) versus an alcohol-based hand gel (Purell) over a 10 minute time frame in producing a persistent reduction on transient bacterial counts isolated from hands seeded with S. marcescens. Aim # 3: Compare user acceptability of silver nanoparticle gel (SilvaSorb) versus an alcohol-based hand gel (Purell) using a self-assessment questionnaire.
Primary Outcome
Subjects' hands are contaminated with 1.5 milliliters (mL) aliquot of S. marcescens which is then distributed evenly over both hands. A 30 second massage with bacteria followed by one minute of timed air drying takes place prior to the modified glove juice sampling procedure. Subject's dominant hand is placed into a sterile 1 liter polyethylene bag with 75 mL of sampling solution. Hand is removed after 60 seconds of massage and 5 mL of juice is retrieved, diluted 1:10 within 5 minutes, and plate
Interventions
- DRUG Silver Nanoparticle Gel
- DRUG alcohol-based hand gel
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2008-01 |
| Est. Completion | 2008-08 |
| Phase | Phase 3 |
Why NCT00659204 stopped before completion
NCT00659204 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Silver Nanoparticle Gel is the first listed.
NCT00659204 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00659204 about?
NCT00659204 is a clinical study titled "Efficacy of Silver Nanoparticle Gel Versus a Common Antibacterial Hand Gel". The purpose of this pilot study is to compare the antimicrobial efficacy of silver nanoparticle gel to a commercialized alcohol-based hand gel on bacterial counts isolated from the hands of 40 volunteers seeded with Serratia marcescens, a surrogate microbial marker. Specific aims of this study are: ...
What is the current status of trial NCT00659204?
This trial is currently terminated. It is a Phase 3 study. The enrollment target is 22 participants. The study started on 2008-01. Estimated completion is 2008-08.
What interventions are being tested in trial NCT00659204?
The interventions under investigation include: Silver Nanoparticle Gel (DRUG), alcohol-based hand gel (DRUG).
Who is sponsoring clinical trial NCT00659204?
This trial is sponsored by Madigan Army Medical Center, which has 22 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00659204's enrollment target sits among peer trials
22 1953rd of 2000 higher than 48 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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