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NCT00650923 · ClinicalTrials.gov registry record · Phase 1
Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
A Phase 1 study, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 61
- Enrollment target
NCT00650923: Completed Phase 1 study, sponsored by National Cancer Institute (NCI).
NCT00650923 is a Phase 1 study that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 61 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00650923, a Phase 1 study, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 61 participants
- Enrollment target
Study Summary
This phase I trial is studying the side effects and best dose of aflibercept when given together with radiation therapy and temozolomide in treating patients with newly diagnosed or recurrent glioblastoma multiforme, gliosarcoma, or other malignant glioma. Aflibercept may stop the growth of tumor cells by blocking blood flow to the tumor. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving aflibercept together with radiation therapy and temozolomide may kill more tumor cells.
Interventions
- DRUG temozolomide
- PROCEDURE laboratory biomarker analysis
- PROCEDURE radiation therapy
- DRUG ziv-aflibercept
- PROCEDURE pharmacological study
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 61 participants |
| Start Date | 2008-07 |
| Est. Completion | 2013-12 |
| Phase | Phase 1 |
What the finished NCT00650923 record still lists
NCT00650923 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 61 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 5 interventions - of which temozolomide is the first listed.
NCT00650923 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00650923 about?
NCT00650923 is a clinical study titled "Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma". This phase I trial is studying the side effects and best dose of aflibercept when given together with radiation therapy and temozolomide in treating patients with newly diagnosed or recurrent glioblastoma multiforme, gliosarcoma, or other malignant glioma. Aflibercept may stop the growth of tumor ce...
What is the current status of trial NCT00650923?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 61 participants. The study started on 2008-07. Estimated completion is 2013-12.
What interventions are being tested in trial NCT00650923?
The interventions under investigation include: temozolomide (DRUG), laboratory biomarker analysis (PROCEDURE), radiation therapy (PROCEDURE), ziv-aflibercept (DRUG), pharmacological study (PROCEDURE).
Who is sponsoring clinical trial NCT00650923?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00650923's enrollment target sits among peer trials
61 828th of 2000 higher than 1,170 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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