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NCT00621829 · ClinicalTrials.gov registry record · NA
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms
A NA study, sponsored by University of California, Davis.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT00621829 is a NA study that has completed, run by University of California, Davis. The registered enrollment target is 30 participants.
The verdict
NCT00621829, a NA study, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
This is a clinical study that is designed to study the effects of the supplemental intake of enriched omega-3 polyunsaturated fatty acids (fish oil) in patients with moderate to severe asthma. Some asthmatics produce a large amount of inflammatory leukotriene proteins-proteins that contribute to wheezing and inflammation in the airway. Inhibiting the detrimental effects of leukotrienes is a key goal of controller therapy in severe asthmatics. Some asthmatic patients appear to have specific mutations of the arachidonate 5-lipoxygenase (ALOX5) gene, one gene that regulates the production of the inflammatory leukotrienes. Omega-3 fatty acids can interfere with the arachidonic acid pathway and decrease the production of leukotrienes, and this may benefit moderate and severe asthma patients. Our hypothesis is that omega-3 fatty acid supplements, added on to a patient's asthma medication regimen, can decrease the number of minor asthma exacerbations compared to patients who do not receive the supplement. Furthermore, we believe that asthma patients with specific ALOX5 gene mutations will benefit most. We will enroll 30 asthma subjects to take part in this trial. They will undergo genotyping of the ALOX5 gene and be treated with omega3-fatty acids (fish oil) and placebo over a nine month period. We expect that this strategy will allow us to discover which moderate and severe asthma patients will benefit most from supplements of omega-3 fatty acids. Treatment of chronic diseases, such as asthma, is a key mission of the Center of Health and Nutrition Research.
Interventions
- DIETARY_SUPPLEMENT EPA enriched fish oils
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2008-02 |
| Est. Completion | 2011-10 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00621829
The ClinicalTrials.gov registry entry for NCT00621829 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Davis, which has 657 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which EPA enriched fish oils is the first listed.
NCT00621829 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00621829 about?
NCT00621829 is a clinical study titled "Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms". This is a clinical study that is designed to study the effects of the supplemental intake of enriched omega-3 polyunsaturated fatty acids (fish oil) in patients with moderate to severe asthma. Some asthmatics produce a large amount of inflammatory leukotriene proteins-proteins that contribute to whe...
What is the current status of trial NCT00621829?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2008-02. Estimated completion is 2011-10.
What interventions are being tested in trial NCT00621829?
The interventions under investigation include: EPA enriched fish oils (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00621829?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
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