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NCT00619073 · ClinicalTrials.gov registry record · NA
PACT (Platelet Activity After Clopidogrel Termination)
A NA study, sponsored by University of Massachusetts, Worcester.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT00619073: Completed NA study, sponsored by University of Massachusetts, Worcester.
NCT00619073 is a NA study that has completed, run by University of Massachusetts, Worcester. The registered enrollment target is 15 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00619073, a NA study, has completed, sponsored by University of Massachusetts, Worcester.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
Clopidogrel is a medication that is used to decrease the ability of platelets to form blood clots. The theory has been proposed that, in patients with coronary artery disease or stroke, increased platelet function after discontinuation of clopidogrel therapy is associated with an increased clotting risk. However, this theory has never been rigorously tested. The goal of this research is to determine whether discontinuation of clopidogrel results in increased platelet function.
Primary Outcome
Value at 45 days after intervention minus value at baseline in platelet surface activated GPIIb-IIIa complex using flow cytometry.The types and concentrations of agonists used in the flow cytometry assays reported here were: ADP 0.5, 1, and 20 µmol/L; thrombin receptor activating peptide (TRAP) 1 and 20 µmol/L; and a combination of collagen 5 µg/mL and epinephrine 5 µmol/L. Mean Florescence Intensity (MFI) is used as unit of measure. MFI indicates relative degree of shift in fluorescence intensi
Interventions
- DRUG placebo
- DRUG Aspirin
- DRUG clopidogrel + aspirin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2008-04 |
| Est. Completion | 2009-05 |
| Phase | NA |
What the finished NCT00619073 record still lists
NCT00619073 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which placebo is the first listed.
NCT00619073 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00619073 about?
NCT00619073 is a clinical study titled "PACT (Platelet Activity After Clopidogrel Termination)". Clopidogrel is a medication that is used to decrease the ability of platelets to form blood clots. The theory has been proposed that, in patients with coronary artery disease or stroke, increased platelet function after discontinuation of clopidogrel therapy is associated with an increased clotting...
What is the current status of trial NCT00619073?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2008-04. Estimated completion is 2009-05.
What interventions are being tested in trial NCT00619073?
The interventions under investigation include: placebo (DRUG), Aspirin (DRUG), clopidogrel + aspirin (DRUG).
Who is sponsoring clinical trial NCT00619073?
This trial is sponsored by University of Massachusetts, Worcester, which has 240 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00619073's enrollment target sits among peer trials
15 1881st of 2000 higher than 92 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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