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NCT00615862 · ClinicalTrials.gov registry record
Relationship Between Alcohol Use Disorders and Cortisol Levels in Patients With Sepsis
A clinical trial, sponsored by Virginia Commonwealth University.
- Completed
- Registry status
- 40
- Enrollment target
NCT00615862 is a clinical trial that has completed, run by Virginia Commonwealth University. The registered enrollment target is 40 participants.
The verdict
NCT00615862 has completed, sponsored by Virginia Commonwealth University.
- COMPLETED
- Registry status
- 40 participants
- Enrollment target
Study Summary
Patients with alcohol use disorders are often cared for in the intensive care unit (ICU). We estimate that close to half of the patients we care for in our ICU have alcohol use disorders. One of the reasons that patients with alcohol use disorders are frequently cared for in our ICU is because patients with alcohol use disorders are at higher risk of developing infections. The medical term for infections is sepsis. When an infection develops, patients with alcohol use disorders tend to get more severely ill compared to patients who do not have alcohol use disorders. Patients with alcohol use disorders are also at higher risk of dying when they develop severe infections. The purpose of this study is to determine why patients with alcohol use disorders become more severely ill when they develop infections. There are a number of reasons why this is possible. One reason is that a hormone called cortisol is higher in individuals with alcohol use disorders (who do not have infections). This hormone is also higher in patients who are at increased risk of dying from severe infections. One of the aims of this study is to see if cortisol levels are higher in patients with alcohol use disorders compared to those who do not have alcohol use disorders. Another reason why patients with alcohol use disorders are at increased risk of developing infections is because their immune system is not functioning properly. A second aim of this study is to see if certain markers of immune function are different in patients with alcohol use disorders compared to patients without alcohol use disorders. Patients with alcohol use disorders are also more likely to become confused when they are in the ICU. This condition is called delirium. Delirium is marked by abrupt onset of altered level of consciousness, disorganized thinking, and inattention that changes over time. Delirium tremens is one form of delirium. About 80% of our ICU patients develop delirium, and many patients who do not have a
Interventions
- OTHER Observational study; no interventions
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2008-03 |
| Est. Completion | 2009-05 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00615862
The ClinicalTrials.gov registry entry for NCT00615862 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Virginia Commonwealth University, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Observational study; no interventions is the first listed.
NCT00615862 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00615862 about?
NCT00615862 is a clinical study titled "Relationship Between Alcohol Use Disorders and Cortisol Levels in Patients With Sepsis". Patients with alcohol use disorders are often cared for in the intensive care unit (ICU). We estimate that close to half of the patients we care for in our ICU have alcohol use disorders. One of the reasons that patients with alcohol use disorders are frequently cared for in our ICU is because patie...
What is the current status of trial NCT00615862?
This trial is currently completed. The enrollment target is 40 participants. The study started on 2008-03. Estimated completion is 2009-05.
What interventions are being tested in trial NCT00615862?
The interventions under investigation include: Observational study; no interventions (OTHER).
Who is sponsoring clinical trial NCT00615862?
This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.
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