Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00604019 · ClinicalTrials.gov registry record · Phase 3
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
A Phase 3 study, sponsored by Rush University Medical Center.
- Completed
- Registry status
- Phase 3
- Development phase
- 252
- Enrollment target
NCT00604019: Completed Phase 3 study, sponsored by Rush University Medical Center.
NCT00604019 is a Phase 3 study that has completed, run by Rush University Medical Center. The registered enrollment target is 252 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00604019, a Phase 3 study, has completed, sponsored by Rush University Medical Center.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 252 participants
- Enrollment target
Study Summary
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS criteria. Patients will also be receiving standard of care, early-goal directed therapy including but not limited to fluid resuscitation, appropriate and early antibiotics, source control and evaluation for drotrecogin alpha where deemed appropriate, while being supported for septic shock.
Primary Outcome
We measured 28 day all-cause mortality in randomized patients with septic shock managed with a vasopressor protocol containing either dopamine versus norepinephrine.
Interventions
- DRUG Dopamine
- DRUG Norepinephrine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 252 participants |
| Start Date | 2003-03 |
| Est. Completion | 2009-08 |
| Phase | Phase 3 |
What the finished NCT00604019 record still lists
NCT00604019 is an interventional study that assigns participants to a tested intervention. The registered 252 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 2 interventions - of which Dopamine is the first listed.
NCT00604019 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00604019 about?
NCT00604019 is a clinical study titled "Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock". We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS criteria. Patients will also be receiving standard of care, early-goal di...
What is the current status of trial NCT00604019?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 252 participants. The study started on 2003-03. Estimated completion is 2009-08.
What interventions are being tested in trial NCT00604019?
The interventions under investigation include: Dopamine (DRUG), Norepinephrine (DRUG).
Who is sponsoring clinical trial NCT00604019?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00604019's enrollment target sits among peer trials
252 1246th of 2000 higher than 752 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02314988 · 252 participants · Phase 2
Tranexamic Acid to Reduce Blood Loss in Spine Surgery
- NCT03941756 · 252 participants · NA
Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma
- NCT05219617 · 252 participants · Phase 3
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
- NCT05384158 · 252 participants · NA
Valuation in Depressed Mood, Anhedonia, and Anxiety
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia