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NCT00589888 · ClinicalTrials.gov registry record · NA
FFA-Induced Hypertension and Endothelial Dysfunction
A NA study, sponsored by Emory University.
- Completed
- Registry status
- NA
- Development phase
- 13
- Enrollment target
NCT00589888: Completed NA study, sponsored by Emory University.
NCT00589888 is a NA study that has completed, run by Emory University. The registered enrollment target is 13 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00589888, a NA study, has completed, sponsored by Emory University.
- COMPLETED
- Registry status
- NA
- Development phase
- 13 participants
- Enrollment target
Study Summary
The study is a prospective open label study to examine the effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects. Subjects will receive either 8-hour of intravenous or oral fat loads in either low or high doses or normal saline in random order. Blood samples are drawn and vitals are measured before and after the infusions. Endothelial function and plasma glucose and lipid levels are measured to study the effects.
Primary Outcome
To study the effects of high dose oral fat load on systolic blood pressure (SBP) in healthy obese subjects, subject's baseline SBP is compared to SBP after the infusion. Blood Pressure (BP) was measured with a manual cuff in triplicate on admission when patient was in Supine position. The Blood pressure was measured at admission and at end of the fat load. The BP from the admission are compared to BP after the fat load. A normal systolic blood pressure is lower than 120 mmHg; elevated blood pres
Interventions
- DRUG Normal Saline
- DRUG Intralipid 20% @ 20cc/hour
- DRUG Intralipid 20%@ 40cc/hour
- DIETARY_SUPPLEMENT 32-gram oral fat load
- DIETARY_SUPPLEMENT 64-gram oral fat load
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2006-08 |
| Est. Completion | 2008-08 |
| Phase | NA |
What the finished NCT00589888 record still lists
NCT00589888 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 5 interventions - of which Normal Saline is the first listed.
NCT00589888 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00589888 about?
NCT00589888 is a clinical study titled "FFA-Induced Hypertension and Endothelial Dysfunction". The study is a prospective open label study to examine the effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects. Subjects will receive either 8-hour of intravenous or oral fat loads in either low or hig...
What is the current status of trial NCT00589888?
This trial is currently completed. It is a NA study. The enrollment target is 13 participants. The study started on 2006-08. Estimated completion is 2008-08.
What interventions are being tested in trial NCT00589888?
The interventions under investigation include: Normal Saline (DRUG), Intralipid 20% @ 20cc/hour (DRUG), Intralipid 20%@ 40cc/hour (DRUG), 32-gram oral fat load (DIETARY_SUPPLEMENT), 64-gram oral fat load (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00589888?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00589888's enrollment target sits among peer trials
13 1911th of 2000 higher than 88 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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