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NCT00583167 · ClinicalTrials.gov registry record
CNS (Central Nervous System) Viral Dynamics and Cellular Immunity During AIDS
A clinical trial, sponsored by Vanderbilt University.
- Completed
- Registry status
- 4
- Enrollment target
NCT00583167 is a clinical trial that has completed, run by Vanderbilt University. The registered enrollment target is 4 participants.
The verdict
NCT00583167 has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- 4 participants
- Enrollment target
Study Summary
Understanding whether or not viral replication occurs in the brain during chronic untreated HIV-1 infection is of undeniable importance, and has implications for treatment and research priorities. Evidence suggests that viral replication in the CNS occurs at the extremes of HIV-1 disease. Brain involvement has been reported during acute infection, and there is convincing evidence of CNS viral replication during HIV-associated dementia (HAD) and advanced AIDS. Some human and primate data suggest that viral RNA and proteins may be absent from brains of some individuals with chronic untreated HIV-1 infection despite abundant proviral DNA. However, the extent of viral replication in the brain is not known for most of the 42 million people worldwide living with untreated HIV-1 infection. Why is viral replication in the brain such a pivotal issue? Microglial cells and macrophages are primary targets for intrathecal HIV-1 replication, and this can promote neuronal injury through direct effects of gp120 and tat, and indirect induction of toxic mediators. Low-grade injury over years or decades would likely be deleterious, particularly as the population ages. Because treatment guidelines allow systemic HIV-1 replication to continue until CD4+ T cell counts decline considerably, antiretroviral therapy (ART) is not recommended for many persons living with HIV. Demonstrating replication in the brain during chronic HIV-1 infection may affect treatment strategies and encourage investigation. Identifying factors that modulate intrathecal viral replication is equally important. Anti-HIV-1 cytotoxic T lymphocytes (CTL) partially control systemic viral replication and delay disease progression. Although available data has been provocative, the role of anti-HIV CTL in the CNS has received little attention. To fill this gap we will examine relationships between intrathecal viral replication, CTL responses, and glial activation/proliferation during HIV-1 infection. These studies will b
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2006-03 |
| Est. Completion | 2010-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00583167
The ClinicalTrials.gov registry entry for NCT00583167 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 4 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University, which has 430 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00583167 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00583167 about?
NCT00583167 is a clinical study titled "CNS (Central Nervous System) Viral Dynamics and Cellular Immunity During AIDS". Understanding whether or not viral replication occurs in the brain during chronic untreated HIV-1 infection is of undeniable importance, and has implications for treatment and research priorities. Evidence suggests that viral replication in the CNS occurs at the extremes of HIV-1 disease. Brain invo...
What is the current status of trial NCT00583167?
This trial is currently completed. The enrollment target is 4 participants. The study started on 2006-03. Estimated completion is 2010-07.
Who is sponsoring clinical trial NCT00583167?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
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