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NCT00580957 · ClinicalTrials.gov registry record · NA
The Autonomic Nervous System and the Metabolic Syndrome
A NA study, sponsored by Vanderbilt University.
- Completed
- Registry status
- NA
- Development phase
- 56
- Enrollment target
NCT00580957: Completed NA study, sponsored by Vanderbilt University.
NCT00580957 is a NA study that has completed, run by Vanderbilt University. The registered enrollment target is 56 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00580957, a NA study, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- NA
- Development phase
- 56 participants
- Enrollment target
Study Summary
The overall goal of this proposal is to determine the role of the autonomic nervous system in the insulin resistant state associated with obesity and the metabolic syndrome. Obesity results from an accumulation of excessive fat deposit due to increase caloric intake or decrease energy expenditure, this condition is usually associated with diseases such as hypertension or diabetes, a cluster known as the metabolic syndrome. The first step in the development of the metabolic syndrome is a resistance to the action of insulin. The mechanism underlying insulin resistance in obesity is still unknown, however some investigators have proposed that the autonomic nervous system, particularly the increase sympathetic activation in obesity may play an important role. We have extensive experience studying the role of the autonomic nervous system in the cardiovascular alterations associated with obesity by producing complete autonomic withdrawal with a drug named trimethaphan. We propose to use the same approach to study the role of the autonomic nervous system in the development of insulin resistance in obesity.
Primary Outcome
Glucose infusion rate in mg/kg/min
Interventions
- DRUG Blocked
- DRUG Intact
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2008-08 |
| Est. Completion | 2015-05 |
| Phase | NA |
What the finished NCT00580957 record still lists
NCT00580957 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 56 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Blocked is the first listed.
NCT00580957 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00580957 about?
NCT00580957 is a clinical study titled "The Autonomic Nervous System and the Metabolic Syndrome". The overall goal of this proposal is to determine the role of the autonomic nervous system in the insulin resistant state associated with obesity and the metabolic syndrome. Obesity results from an accumulation of excessive fat deposit due to increase caloric intake or decrease energy expenditure, t...
What is the current status of trial NCT00580957?
This trial is currently completed. It is a NA study. The enrollment target is 56 participants. The study started on 2008-08. Estimated completion is 2015-05.
What interventions are being tested in trial NCT00580957?
The interventions under investigation include: Blocked (DRUG), Intact (DRUG).
Who is sponsoring clinical trial NCT00580957?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00580957's enrollment target sits among peer trials
56 1262nd of 2000 higher than 737 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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