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NCT00575848 · ClinicalTrials.gov registry record · Phase 1
Study of the Effects of Glycine on Symptoms and Memory in Patients With Schizophrenia
A Phase 1 study, sponsored by North Suffolk Mental Health Association.
- Terminated
- Registry status
- Phase 1
- Development phase
- 16
- Enrollment target
NCT00575848 is a Phase 1 study that was terminated before completion, run by North Suffolk Mental Health Association. The registered enrollment target is 16 participants.
The verdict
NCT00575848, a Phase 1 study, was terminated before completion, sponsored by North Suffolk Mental Health Association.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 16 participants
- Enrollment target
Study Summary
The goal of this project is to understand whether glycine is helpful for improving some symptoms of schizophrenia such as low motivation, loss of interest, and social isolation. In addition, the investigators want to find out if glycine improves memory. This project involves a three-and-a-half month trial of glycine or placebo. A placebo looks exactly like the study drug, but it contains no active drug. Glycine is a naturally occurring substance that is a part of some of the proteins in your body. Glycine has not been approved by the FDA (Food and Drug Administration) for the treatment of schizophrenia. However, the FDA allows it to be used in research studies. Related Study at McLean Hospital: If you would like to participate in this study of glycine versus placebo at the Freedom Trail Clinic, the investigators will ask you if you would also like to participate in a related study at McLean Hospital. The study at McLean Hospital will look at the effects of glycine and placebo on levels of glycine in the brain. The study will use magnetic resonance spectroscopy to measure brain glycine levels. The magnetic resonance (MR) scanner looks like a large cylinder with a tube running down the center. You will be asked to lie down on your back on a foam-padded table and place your head into a special holder. The table will slide you inside the "hole" of the scanner. Soft foam rubber sponges may be placed on both sides of your head for comfort and to help keep your head from moving. Because the scanner contains a strong magnet, you will be asked to remove all metal objects from your person including, but not limited to: watches, rings, necklaces, bracelets, earrings and other body piercings, belts, loose change, wallet (with credit cards), items of clothing containing magnetic materials (for example, underwire bras, certain types of zippers), and shoes. These items will be secured in a safe place until your scan is completed. You will be able to remain in your street clothes
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT Glycine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2007-12 |
| Est. Completion | 2008-10 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00575848
The ClinicalTrials.gov registry entry for NCT00575848 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 16 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is North Suffolk Mental Health Association, which has 11 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00575848 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00575848 about?
NCT00575848 is a clinical study titled "Study of the Effects of Glycine on Symptoms and Memory in Patients With Schizophrenia". The goal of this project is to understand whether glycine is helpful for improving some symptoms of schizophrenia such as low motivation, loss of interest, and social isolation. In addition, the investigators want to find out if glycine improves memory. This project involves a three-and-a-half mont...
What is the current status of trial NCT00575848?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 16 participants. The study started on 2007-12. Estimated completion is 2008-10.
What interventions are being tested in trial NCT00575848?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Glycine (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00575848?
This trial is sponsored by North Suffolk Mental Health Association, which has 11 total clinical trials registered on ClinicalTrials.gov.
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