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NCT00573898 · ClinicalTrials.gov registry record
Daptomycin Study - Collection of Pharmacokinetic Samples in Patients With Renal Failure
A clinical trial of Renal Failure, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 5
- Enrollment target
- 1
- Study location
NCT00573898 is a study of Renal Failure that has completed, run by University of Pittsburgh. The registered enrollment target is 5 participants, below the 301-participant average among 11 other Renal Failure trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT00573898, a study of Renal Failure, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
This will be a prospective, multicenter, open-labeled, non-comparative pharmacokinetic study conducted in 10 critically ill, anuric patients receiving CVVHDF. Enrollment will take place at 3-5 clinical sites in the United States. A study coordinator at each site will be identified and institutional specific processes (e.g., pharmacy records, etc.) will be utilized to identify patients. Full evaluation of inclusion and exclusion criteria will be conducted by each site's coordinator within 48 hours of initiation of daptomycin therapy. Subjects receiving daptomycin 6mg/kg (total body weight) once daily for a suspected/documented infection, as deemed necessary by the treating clinician will be screened for inclusion in the current study. Dialysate, ultrafiltrate, and blood flow rate utilized during the CVVHDF procedure will be determined by clinicians at discretion to optimize stability of patients. Daptomycin samples will be obtained around the third dose in an attempt to achieve approximate steady-state concentrations. Pre- and post-filter blood samples will be collected simultaneously with dialysate and ultrafiltrate specimens at multiple time points. Protein binding will be assessed by filtration of the serum samples at the peak drug concentration time points.
Conditions Studied
Study Locations (1)
Pennsylvania
- UPMC - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2008-03 |
| Est. Completion | 2010-12 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00573898
The ClinicalTrials.gov registry entry for NCT00573898 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 301-participant average among 11 other Renal Failure trials with a reported enrollment target (98% lower). The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Renal Failure appearing as the primary indexed condition, and to 0 interventions.
NCT00573898 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT00573898 about?
NCT00573898 is a clinical study titled "Daptomycin Study - Collection of Pharmacokinetic Samples in Patients With Renal Failure". This will be a prospective, multicenter, open-labeled, non-comparative pharmacokinetic study conducted in 10 critically ill, anuric patients receiving CVVHDF. Enrollment will take place at 3-5 clinical sites in the United States. A study coordinator at each site will be identified and institutional ...
What is the current status of trial NCT00573898?
This trial is currently completed. The enrollment target is 5 participants. The study started on 2008-03. Estimated completion is 2010-12.
What conditions does trial NCT00573898 study?
This clinical trial studies the following conditions: Renal Failure.
Who is sponsoring clinical trial NCT00573898?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00573898 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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