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NCT00573300 · ClinicalTrials.gov registry record
Disturbances of Kynurenine Pathway of Trytophan Metabolism in Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study
A clinical trial, sponsored by North Suffolk Mental Health Association.
- Completed
- Registry status
- 60
- Enrollment target
NCT00573300: Completed study, sponsored by North Suffolk Mental Health Association.
NCT00573300 is a clinical trial that has completed, run by North Suffolk Mental Health Association. The registered enrollment target is 60 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00573300 has completed, sponsored by North Suffolk Mental Health Association.
- COMPLETED
- Registry status
- 60 participants
- Enrollment target
Study Summary
In this pilot study, the investigators propose to characterize the pattern of activation of the kynurenine pathway of tryptophan metabolism in peripheral macrophages of patients with schizophrenia. To do this, the investigators will measure the gene expression of several major enzymes in this pathway in macrophages, including the key enzyme involved in tryptophan to kynurenine metabolism, IDO, by means of quantitative reverse-transcription polymerase chain reaction (RT-PCR). The focus on enzyme mRNA expression as opposed to serum or cerebrospinal fluid levels of metabolites provides a possibly more sensitive characterization of the activation of this metabolic pathway.
Interventions
- PROCEDURE Phlebotomy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2006-01 |
| Est. Completion | 2009-05 |
What the finished NCT00573300 record still lists
NCT00573300 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Phlebotomy is the first listed.
NCT00573300 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00573300 about?
NCT00573300 is a clinical study titled "Disturbances of Kynurenine Pathway of Trytophan Metabolism in Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study". In this pilot study, the investigators propose to characterize the pattern of activation of the kynurenine pathway of tryptophan metabolism in peripheral macrophages of patients with schizophrenia. To do this, the investigators will measure the gene expression of several major enzymes in this pathwa...
What is the current status of trial NCT00573300?
This trial is currently completed. The enrollment target is 60 participants. The study started on 2006-01. Estimated completion is 2009-05.
What interventions are being tested in trial NCT00573300?
The interventions under investigation include: Phlebotomy (PROCEDURE).
Who is sponsoring clinical trial NCT00573300?
This trial is sponsored by North Suffolk Mental Health Association, which has 11 total clinical trials registered on ClinicalTrials.gov.
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