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NCT00560469 · ClinicalTrials.gov registry record
Impaired Adipogenesis in Insulin Resistance: Pilot Clinical and In Vitro Studies
A clinical trial, sponsored by University of Vermont.
- Completed
- Registry status
- 20
- Enrollment target
NCT00560469: Completed study, sponsored by University of Vermont.
NCT00560469 is a clinical trial that has completed, run by University of Vermont. The registered enrollment target is 20 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00560469 has completed, sponsored by University of Vermont.
- COMPLETED
- Registry status
- 20 participants
- Enrollment target
Study Summary
Obesity is a strong risk factor for developing type 2 diabetes (T2DM), but the reasons for this are not fully understood. In particular, it is not known why some obese people develop T2DM while other obese individuals do not. This study tests whether differences in fat cells (adipocytes) are to blame. Even in adults, fat cells are constantly being formed to replace old fat cells and to respond to the body's need to store excess energy. The ability to form new fat cells may be diminished in some individuals, leading to larger fat cells. These large fat cells secrete hormones that may increase risk for T2DM. This study tests whether fat cells from obese insulin resistant subjects (who are at risk for developing T2DM) form at a slower rate than those from insulin sensitive subjects (who are at lower risk for developing T2DM). To address this question we will recruit and study two groups of obese subjects, selected to be similar in age, gender and degree of obesity. One group of subjects will be obese and insulin resistant (the OIR group), while the other will be comparably obese, but insulin sensitive (OIS). Subjects will undergo a series of studies to characterize their metabolism including measurement of body fat by DEXA scanning, oral glucose tolerance (a test used to diagnose diabetes) and measurement of insulin sensitivity in response to an infusion of insulin (a research study used to classify patients into the OIR and OIS groups). Small samples of fat (from just under the skin of the belly and the buttocks) will obtained using a needle on two occasions over 12 weeks. During these 12 weeks, subjects will drink a small amount of water that contains a non-radioactive label. This labeled water will allow us to measure the rate of growth of new fat cells in the body. We will also look at the rate of growth of fat cells obtained from these biopsies in the laboratory. The results of this study may tell us more about why certain obese people develop diabetes and why o
Interventions
- OTHER Administration of 70% deuterated water
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2008-01 |
| Est. Completion | 2010-07 |
What the finished NCT00560469 record still lists
NCT00560469 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Administration of 70% deuterated water is the first listed.
NCT00560469 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00560469 about?
NCT00560469 is a clinical study titled "Impaired Adipogenesis in Insulin Resistance: Pilot Clinical and In Vitro Studies". Obesity is a strong risk factor for developing type 2 diabetes (T2DM), but the reasons for this are not fully understood. In particular, it is not known why some obese people develop T2DM while other obese individuals do not. This study tests whether differences in fat cells (adipocytes) are to blam...
What is the current status of trial NCT00560469?
This trial is currently completed. The enrollment target is 20 participants. The study started on 2008-01. Estimated completion is 2010-07.
What interventions are being tested in trial NCT00560469?
The interventions under investigation include: Administration of 70% deuterated water (OTHER).
Who is sponsoring clinical trial NCT00560469?
This trial is sponsored by University of Vermont, which has 162 total clinical trials registered on ClinicalTrials.gov.
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