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NCT00548886 · ClinicalTrials.gov registry record · NA
Low-dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients
A NA study, sponsored by Emory University.
- Terminated
- Registry status
- NA
- Development phase
- 7
- Enrollment target
NCT00548886 is a NA study that was terminated before completion, run by Emory University. The registered enrollment target is 7 participants.
The verdict
NCT00548886, a NA study, was terminated before completion, sponsored by Emory University.
- TERMINATED
- Registry status
- NA
- Development phase
- 7 participants
- Enrollment target
Study Summary
Long QT syndrome (LQTS)is a cardiac disorder that may lead to ventricular arrythmias and culminate in syncope and/or possible death. Recently, researchers have developed a way of discovering patients with LQTS by using low doses of epinephrine by a continuous, intravenous infusion in adults. Epinephrine, or adrenaline, is produced by our bodies in times of stress. By producing adrenaline, your body allows itself to adapt to its stressful environment and take appropriate actions (i.e. fight or flight response). By simulating this response with very small amounts of epinephrine, researchers have shown prolongation of the QT interval does not occur in normal healthy adults. However, adults with confirmed LQTS Type 1 (LQTS-1) will prolong their QT interval when given low dose epinephrine. Therefore, this test can act as a safe means of identifying adults with LQTS-1 who do not have prolonged QT intervals on their resting EKGs. However, LQTS is not just a disease of adults, it affects children as well. Currently the standard of care is to obtain resting EKGs on our pediatric patients which can miss those patients with concealed LQTS. Those patients, who are old enough, can undergo exercise testing. Yet this leaves young children unable to run on a treadmill without a diagnostic test. Hypothesis: The low-dose epinephrine infusion stress test does not cause prolongation of the QT interval in an electrophysiologically normal healthy pediatric population.
Interventions
- DRUG Epinephrine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2008-02 |
| Est. Completion | 2012-06 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00548886
The ClinicalTrials.gov registry entry for NCT00548886 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 7 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Emory University, which has 1,208 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Epinephrine is the first listed.
NCT00548886 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00548886 about?
NCT00548886 is a clinical study titled "Low-dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients". Long QT syndrome (LQTS)is a cardiac disorder that may lead to ventricular arrythmias and culminate in syncope and/or possible death. Recently, researchers have developed a way of discovering patients with LQTS by using low doses of epinephrine by a continuous, intravenous infusion in adults. Epinep...
What is the current status of trial NCT00548886?
This trial is currently terminated. It is a NA study. The enrollment target is 7 participants. The study started on 2008-02. Estimated completion is 2012-06.
What interventions are being tested in trial NCT00548886?
The interventions under investigation include: Epinephrine (DRUG).
Who is sponsoring clinical trial NCT00548886?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
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