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NCT00544453 · ClinicalTrials.gov registry record · Phase 1
Evaluation of [123I] MNI-308 and SPECT as a Marker of Beta-amyloid Protein Deposition in AD Subjects Compared to HC
A Phase 1 study, sponsored by Molecular NeuroImaging.
- Terminated
- Registry status
- Phase 1
- Development phase
- 2
- Enrollment target
NCT00544453: Clinical Trial Phase 1 study, sponsored by Molecular NeuroImaging.
NCT00544453 is a Phase 1 study that was terminated before completion, run by Molecular NeuroImaging. The registered enrollment target is 2 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00544453, a Phase 1 study, was terminated before completion, sponsored by Molecular NeuroImaging.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 2 participants
- Enrollment target
Study Summary
The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I MNI-308, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT) in similarly aged Alzheimer's (AD) subjects and healthy controls To perform blood metabolite characterization of 123-I MNI-308 in healthy and AD subjects to determine the metabolic fate and nature of metabolites in assessment of 123-I MNI-308 as a single photon computed tomography (SPECT) brain imaging agent Evaluate the test/retest reproducibility of 123-I MNI-308 and SPECT in AD subjects and healthy control
Interventions
- DRUG [123I] MNI-308
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2007-10 |
| Est. Completion | 2008-07 |
| Phase | Phase 1 |
Why NCT00544453 stopped before completion
NCT00544453 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which [123I] MNI-308 is the first listed.
NCT00544453 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00544453 about?
NCT00544453 is a clinical study titled "Evaluation of [123I] MNI-308 and SPECT as a Marker of Beta-amyloid Protein Deposition in AD Subjects Compared to HC". The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I MNI-308, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT) in similarly aged Alzheimer's (AD) subjects and healthy controls To ...
What is the current status of trial NCT00544453?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 2 participants. The study started on 2007-10. Estimated completion is 2008-07.
What interventions are being tested in trial NCT00544453?
The interventions under investigation include: [123I] MNI-308 (DRUG).
Who is sponsoring clinical trial NCT00544453?
This trial is sponsored by Molecular NeuroImaging, which has 13 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00544453's enrollment target sits among peer trials
2 2000th of 2000 the lowest of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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