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NCT00527345 · ClinicalTrials.gov registry record
Children's Exposures/Health Effects/Diesel Exhaust
A clinical trial of Asthma and Airway Inflammation, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Completed
- Registry status
- 450
- Enrollment target
- 1
- Study location
NCT00527345 is a study of Asthma and Airway Inflammation that has completed, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 450 participants, below the 1,562-participant average among 374 other Asthma trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.
The verdict
NCT00527345, a study of Asthma and Airway Inflammation, has completed, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- COMPLETED
- Registry status
- 450 participants
- Enrollment target
- 1
- Study location
Study Summary
The contribution of diesel exhaust (DE) to health, especially children's health, is of tremendous public health interest. DE has been associated with worsening asthma and allergies, among other important health effects. Reducing DE exposures has become a major regulatory initiative, and federal, state, and local jurisdictions are investing hundreds of millions of dollars in retrofitting diesel engines in school buses and other changes to reach this goal. The U.S. Environmental Protection Agency's recent regulations require all on-road diesel vehicles to change to low emission engines and ultra-low-sulfur fuels by 2007 (US EPA '00). In spring 2003, the U.S. EPA announced a nationwide voluntary school bus retrofit initiative. In July 2003, the Washington Legislature enacted a statewide "Diesel Solutions" program that provides 25 million dollars by 2008 to retrofit school diesel buses with cleaner burning engines and fuels, making it one of the largest and most active voluntary school bus retrofit program in the country. If risk assessment estimates are accurate, these changes will have a large public health impact, especially on children who ride school buses daily. However, no studies to-date have rigorously examined school children's exposure to diesel exhaust (DE) and its health effects, nor such a significant change in vehicular pollution control. We propose to seize this opportunity of a large natural experiment taking place in the Puget Sound area and conduct a study to assess health effects from diesel bus exhaust before and after the retrofit of diesel bus fleets between 2005 and 2007. The specific aims of the study are to: 1. Determine whether asthmatic children changing to retrofitted buses with cleaner fuels and engines have a reduction in sub-clinical and clinical asthma severity. 2. Determine if increased levels of DE exposure lead to an increase in acute clinical and sub-clinical features of asthma in children. 3. Quantify the levels and changes in par
Conditions Studied
Study Locations (1)
Washington
- University of Washington Dept. Environmental and Occupational Health Sciences - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 450 participants |
| Start Date | 2005-03 |
| Est. Completion | 2009-07 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00527345
The ClinicalTrials.gov registry entry for NCT00527345 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 450 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,562-participant average among 374 other Asthma trials with a reported enrollment target (71% lower). The listed sponsor is National Institute of Environmental Health Sciences (NIEHS), which has 145 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Asthma appearing as the primary indexed condition, and to 0 interventions.
NCT00527345 reports 1 study location spanning 1 distinct geographic area - top geographies include Washington.
Frequently Asked Questions
What is clinical trial NCT00527345 about?
NCT00527345 is a clinical study titled "Children's Exposures/Health Effects/Diesel Exhaust". The contribution of diesel exhaust (DE) to health, especially children's health, is of tremendous public health interest. DE has been associated with worsening asthma and allergies, among other important health effects. Reducing DE exposures has become a major regulatory initiative, and federal, sta...
What is the current status of trial NCT00527345?
This trial is currently completed. The enrollment target is 450 participants. The study started on 2005-03. Estimated completion is 2009-07.
What conditions does trial NCT00527345 study?
This clinical trial studies the following conditions: Asthma, Airway Inflammation.
Who is sponsoring clinical trial NCT00527345?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00527345 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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