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NCT00524186 · ClinicalTrials.gov registry record · Phase 1
Sunitinib, Irinotecan, Fluorouracil, and Leucovorin In Treating Patients With Advanced Stomach Cancer or Gastroesophageal Cancer
A Phase 1 study, sponsored by Roswell Park Cancer Institute.
- Terminated
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
NCT00524186: Clinical Trial Phase 1 study, sponsored by Roswell Park Cancer Institute.
NCT00524186 is a Phase 1 study that was terminated before completion, run by Roswell Park Cancer Institute. The registered enrollment target is 23 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00524186, a Phase 1 study, was terminated before completion, sponsored by Roswell Park Cancer Institute.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
Study Summary
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sunitinib together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of sunitinib when given together with irinotecan, fluorouracil, and leucovorin in treating patients with advanced stomach cancer or gastroesophageal cancer.
Interventions
- DRUG fluorouracil
- DRUG leucovorin calcium
- OTHER flow cytometry
- DRUG irinotecan hydrochloride
- DRUG sunitinib malate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2007-05 |
| Est. Completion | 2016-04 |
| Phase | Phase 1 |
Why NCT00524186 stopped before completion
NCT00524186 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 5 interventions - of which fluorouracil is the first listed.
NCT00524186 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00524186 about?
NCT00524186 is a clinical study titled "Sunitinib, Irinotecan, Fluorouracil, and Leucovorin In Treating Patients With Advanced Stomach Cancer or Gastroesophageal Cancer". RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by ki...
What is the current status of trial NCT00524186?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2007-05. Estimated completion is 2016-04.
What interventions are being tested in trial NCT00524186?
The interventions under investigation include: fluorouracil (DRUG), leucovorin calcium (DRUG), flow cytometry (OTHER), irinotecan hydrochloride (DRUG), sunitinib malate (DRUG).
Who is sponsoring clinical trial NCT00524186?
This trial is sponsored by Roswell Park Cancer Institute, which has 365 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00524186's enrollment target sits among peer trials
23 1596th of 2000 higher than 400 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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