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NCT00504894 · ClinicalTrials.gov registry record · Phase 4
Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
A Phase 4 study, sponsored by Weill Medical College of Cornell University.
- Terminated
- Registry status
- Phase 4
- Development phase
- 60
- Enrollment target
NCT00504894: Clinical Trial Phase 4 study, sponsored by Weill Medical College of Cornell University.
NCT00504894 is a Phase 4 study that was terminated before completion, run by Weill Medical College of Cornell University. The registered enrollment target is 60 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (88% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00504894, a Phase 4 study, was terminated before completion, sponsored by Weill Medical College of Cornell University.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 60 participants
- Enrollment target
Study Summary
This study involves 60 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable. This dissociation pattern will be different between the drugs propofol and thiopental.
Primary Outcome
Three anatomical regions for which there was an a priori mechanistic hypothesis were assessed using standard small volume correction: (i) the amygdala, bilaterally; (ii) the hippocampus, bilaterally; and (iii) the parahippocampus, bilaterally. Using single-tailed t tests, a priori regions were reported as significant if the initial uncorrected voxel-wise P value was \< 0.001, and then the P value was \< 0.05 after family-wise error correction for multiple comparisons in the hypothesized anatomic
Interventions
- DRUG Placebo
- DRUG Propofol
- DRUG Thiopental
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2007-03 |
| Est. Completion | 2013-11 |
| Phase | Phase 4 |
Why NCT00504894 stopped before completion
NCT00504894 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (88% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT00504894 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00504894 about?
NCT00504894 is a clinical study titled "Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes". This study involves 60 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a se...
What is the current status of trial NCT00504894?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 60 participants. The study started on 2007-03. Estimated completion is 2013-11.
What interventions are being tested in trial NCT00504894?
The interventions under investigation include: Placebo (DRUG), Propofol (DRUG), Thiopental (DRUG).
Who is sponsoring clinical trial NCT00504894?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00504894's enrollment target sits among peer trials
60 1125th of 2000 higher than 799 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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