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NCT00501280 · ClinicalTrials.gov registry record
Genetic Susceptibility in Migrant Farmworker Children
A clinical trial, sponsored by M.D. Anderson Cancer Center.
- Completed
- Registry status
- 768
- Enrollment target
NCT00501280: Completed study, sponsored by M.D. Anderson Cancer Center.
NCT00501280 is a clinical trial that has completed, run by M.D. Anderson Cancer Center. The registered enrollment target is 768 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00501280 has completed, sponsored by M.D. Anderson Cancer Center.
- COMPLETED
- Registry status
- 768 participants
- Enrollment target
Study Summary
Primary Objectives: 1. To test the hypothesis that children whose mothers are Migrant/Seasonal Farmworkers (MSFs) (occupationally-exposed to pesticides) may be at a higher risk for exhibiting mutagen-induced DNA damage than children whose mothers and fathers are not MSFs. 2. To test the hypothesis that MSF mothers (occupationally-exposed to pesticides) may be at a higher risk for exhibiting mutagen-induced DNA damage than mothers who are not MSFs. Secondary Objectives: 1. To test the hypothesis that both the extent of pesticide exposure and the type of polymorphisms in chemical detoxification genes and DNA repair genes contribute to the extent of cytogenetic damage found in children of MSF women. 2. To test the hypothesis that both the extent of pesticide exposure and the type of polymorphisms in chemical detoxification genes and DNA repair genes contribute to the extent of cytogenetic damage found in MSF mothers. 3. To test the hypothesis that the total concentration levels of organochlorine (OCP) and organophosphate (OP) pesticides will correlate with the mutagenic potency of the serum and urine of the children. 4. To test the hypothesis that the total concentration levels of OCP and OP pesticides will correlate with the mutagenic potency of the serum and urine of the mothers. 5. To test the hypothesis that inherited polymorphisms in the PON1 gene and its expression modulate the risk for OP genotoxicity measured by the inhibition of the acetylcholinesterase enzyme in MSF children. 6. To test the hypothesis that inherited polymorphisms in the PON1 gene and its expression modulate the risk for OP genotoxicity measured by the inhibition of the acetylcholinesterase enzyme in MSF mothers.
Interventions
- BEHAVIORAL Interview
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 768 participants |
| Start Date | 2004-06 |
| Est. Completion | 2013-02 |
What the finished NCT00501280 record still lists
NCT00501280 is an observational study that tracks outcomes without assigning an intervention. The registered 768 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Interview is the first listed.
NCT00501280 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00501280 about?
NCT00501280 is a clinical study titled "Genetic Susceptibility in Migrant Farmworker Children". Primary Objectives: 1. To test the hypothesis that children whose mothers are Migrant/Seasonal Farmworkers (MSFs) (occupationally-exposed to pesticides) may be at a higher risk for exhibiting mutagen-induced DNA damage than children whose mothers and fathers are not MSFs. 2. To test the hypothesis ...
What is the current status of trial NCT00501280?
This trial is currently completed. The enrollment target is 768 participants. The study started on 2004-06. Estimated completion is 2013-02.
What interventions are being tested in trial NCT00501280?
The interventions under investigation include: Interview (BEHAVIORAL).
Who is sponsoring clinical trial NCT00501280?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
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