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NCT00490490 · ClinicalTrials.gov registry record · Phase 2
Study of Bexxar <Tositumomab> Combined With External Beam Radiation Therapy
A Phase 2 study, sponsored by Stanford University.
- Terminated
- Registry status
- Phase 2
- Development phase
- 8
- Enrollment target
NCT00490490: Clinical Trial Phase 2 study, sponsored by Stanford University.
NCT00490490 is a Phase 2 study that was terminated before completion, run by Stanford University. The registered enrollment target is 8 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00490490, a Phase 2 study, was terminated before completion, sponsored by Stanford University.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 8 participants
- Enrollment target
Study Summary
The purpose of the study is to assess the response rate of patients with relapsed or refractory low-grade or transformed low-grade, CD20-positive, B-cell non-Hodgkin's lymphoma to Iodine-131 (I-131) tositumomab (Bexxar) therapy plus local palliative radiation therapy (XRT).
Primary Outcome
Participants assessed for by the following Complete Response (CR) criteria CR or Functional CR * No evidence of disease and symptoms * Any macroscopic nodules detected in any organs no longer present. * Any palpable lymph node is normal and greatest diameter is \< 1.0 cm. * The enlarged organs decreased in size and not palpable * The bone marrow biopsy and aspirate are negative for disease * Negative for disease by PET-scan (functional CR) CR Unconfirmed (CRu) criteria * No evidence of disea
Interventions
- DRUG Potassium Iodide (KI)
- DRUG Bexxar (tositumomab)
- PROCEDURE External beam radiotherapy (XRT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2007-01 |
| Est. Completion | 2013-07 |
| Phase | Phase 2 |
Why NCT00490490 stopped before completion
NCT00490490 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 3 interventions - of which Potassium Iodide (KI) is the first listed.
NCT00490490 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00490490 about?
NCT00490490 is a clinical study titled "Study of Bexxar <Tositumomab> Combined With External Beam Radiation Therapy". The purpose of the study is to assess the response rate of patients with relapsed or refractory low-grade or transformed low-grade, CD20-positive, B-cell non-Hodgkin's lymphoma to Iodine-131 (I-131) tositumomab (Bexxar) therapy plus local palliative radiation therapy (XRT).
What is the current status of trial NCT00490490?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 8 participants. The study started on 2007-01. Estimated completion is 2013-07.
What interventions are being tested in trial NCT00490490?
The interventions under investigation include: Potassium Iodide (KI) (DRUG), Bexxar (tositumomab) (DRUG), External beam radiotherapy (XRT) (PROCEDURE).
Who is sponsoring clinical trial NCT00490490?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00490490's enrollment target sits among peer trials
8 1990th of 2000 higher than 5 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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