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NCT00484159 · ClinicalTrials.gov registry record · NA
Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 151
- Enrollment target
NCT00484159: Completed NA study, sponsored by Johns Hopkins University.
NCT00484159 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 151 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00484159, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 151 participants
- Enrollment target
Study Summary
Lumbar zygapophysial (facet) joint pain is a common cause of low back pain. Radiofrequency (RF) denervation is an effective and low risk treatment of chronic low back pain of suspected facet joint etiology. Blocks of the medial branches innervating the joints are commonly used to localize the pain and make the diagnosis of facet joint pain. There is currently no standard number of diagnostic blocks: zero, one, and two blocks have all been utilized. Considering the high false positive and false negative rates of these blocks, the cost: benefit ratio has been questioned. No study to date has examined the practice of diagnostic medial branch blocks before RF denervation. The purpose of this study is to determine the optimal number of blocks before radiofrequency denervation. Three groups of patients will be studied. In group I, patients will undergo RF denervation based on history and physical exam alone. In group II, patients will undergo RF denervation based on a positive response to a single diagnostic block with local anesthetic. In group III, patients will undergo RF treatment only after a positive screening block and a positive confirmatory block.
Primary Outcome
Total cost per effective treatment at 3-months. Successful procedure defined as greater or equal to 50% pain relief and satisfaction lasting at least 3 months.
Interventions
- DRUG 0.5% bupivacaine
- PROCEDURE Radiofrequency denervation of medial branches
- DRUG 2% lidocaine
- PROCEDURE Radiofrequency denervation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 151 participants |
| Start Date | 2007-02 |
| Est. Completion | 2009-01 |
| Phase | NA |
What the finished NCT00484159 record still lists
NCT00484159 is an interventional study that assigns participants to a tested intervention. The registered 151 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 4 interventions - of which 0.5% bupivacaine is the first listed.
NCT00484159 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00484159 about?
NCT00484159 is a clinical study titled "Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation". Lumbar zygapophysial (facet) joint pain is a common cause of low back pain. Radiofrequency (RF) denervation is an effective and low risk treatment of chronic low back pain of suspected facet joint etiology. Blocks of the medial branches innervating the joints are commonly used to localize the pain a...
What is the current status of trial NCT00484159?
This trial is currently completed. It is a NA study. The enrollment target is 151 participants. The study started on 2007-02. Estimated completion is 2009-01.
What interventions are being tested in trial NCT00484159?
The interventions under investigation include: 0.5% bupivacaine (DRUG), Radiofrequency denervation of medial branches (PROCEDURE), 2% lidocaine (DRUG), Radiofrequency denervation (PROCEDURE).
Who is sponsoring clinical trial NCT00484159?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00484159's enrollment target sits among peer trials
151 661st of 2000 higher than 1,340 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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