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NCT00481182 · ClinicalTrials.gov registry record · Phase 1
Co-Administration Of Fosamprenavir With Methadone: A Drug Interaction Study.
A Phase 1 study, sponsored by GlaxoSmithKline.
- Completed
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT00481182: Completed Phase 1 study, sponsored by GlaxoSmithKline.
NCT00481182 is a Phase 1 study that has completed, run by GlaxoSmithKline. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00481182, a Phase 1 study, has completed, sponsored by GlaxoSmithKline.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
To assess the combined effects of fosamprenavir 700mg BID + ritonavir 100mg BID + standardized dose of methadone, on plasma total and unbound methadone enantiomer pharmacokinetics (PK), opiate pharmacodynamic (PD) measures, and safety. The effect of methadone on plasma amprenavir PK will also be assessed by comparison to historical control data.
Interventions
- DRUG fosamprenavir + ritonavir + methadone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2005-02 |
| Phase | Phase 1 |
What the finished NCT00481182 record still lists
NCT00481182 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 1 intervention - of which fosamprenavir + ritonavir + methadone is the first listed.
NCT00481182 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00481182 about?
NCT00481182 is a clinical study titled "Co-Administration Of Fosamprenavir With Methadone: A Drug Interaction Study.". To assess the combined effects of fosamprenavir 700mg BID + ritonavir 100mg BID + standardized dose of methadone, on plasma total and unbound methadone enantiomer pharmacokinetics (PK), opiate pharmacodynamic (PD) measures, and safety. The effect of methadone on plasma amprenavir PK will also be ass...
What is the current status of trial NCT00481182?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2005-02.
What interventions are being tested in trial NCT00481182?
The interventions under investigation include: fosamprenavir + ritonavir + methadone (DRUG).
Who is sponsoring clinical trial NCT00481182?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00481182's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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