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NCT00474903 · ClinicalTrials.gov registry record · Phase 2
Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus
A Phase 2 study, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 2
- Development phase
- 122
- Enrollment target
NCT00474903: Completed Phase 2 study, sponsored by National Cancer Institute (NCI).
NCT00474903 is a Phase 2 study that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 122 participants, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00474903, a Phase 2 study, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 122 participants
- Enrollment target
Study Summary
This randomized phase II trial is studying the effect of esomeprazole magnesium and aspirin on tissue PGE2 levels compared with esomeprazole and placebo. This type of chemoprevention treatment investigates the use of certain drugs to assess whether they assist in the prevention of cancer. The use of esomeprazole magnesium with or without aspirin may help prevent esophageal cancer in patients with Barrett esophagus.
Primary Outcome
The mean tissue PGE2 is reported for each Arm.
Interventions
- OTHER placebo
- DRUG acetylsalicylic acid
- DRUG esomeprazole magnesium
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 122 participants |
| Start Date | 2007-04 |
| Est. Completion | 2011-06 |
| Phase | Phase 2 |
What the finished NCT00474903 record still lists
NCT00474903 is an interventional study that assigns participants to a tested intervention. The registered 122 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target.
The record links to 0 conditions, and to 3 interventions - of which placebo is the first listed.
NCT00474903 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00474903 about?
NCT00474903 is a clinical study titled "Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus". This randomized phase II trial is studying the effect of esomeprazole magnesium and aspirin on tissue PGE2 levels compared with esomeprazole and placebo. This type of chemoprevention treatment investigates the use of certain drugs to assess whether they assist in the prevention of cancer. The use of...
What is the current status of trial NCT00474903?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 122 participants. The study started on 2007-04. Estimated completion is 2011-06.
What interventions are being tested in trial NCT00474903?
The interventions under investigation include: placebo (OTHER), acetylsalicylic acid (DRUG), esomeprazole magnesium (DRUG).
Who is sponsoring clinical trial NCT00474903?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00474903's enrollment target sits among peer trials
122 565th of 2000 higher than 1,434 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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