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NCT00470392 · ClinicalTrials.gov registry record · NA
Mechanistically-based Optimization of UV Radiation Therapy in Psoriasis
A NA study, sponsored by VA Office of Research and Development.
- Terminated
- Registry status
- NA
- Development phase
- 9
- Enrollment target
NCT00470392: Clinical Trial NA study, sponsored by VA Office of Research and Development.
NCT00470392 is a NA study that was terminated before completion, run by VA Office of Research and Development. The registered enrollment target is 9 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00470392, a NA study, was terminated before completion, sponsored by VA Office of Research and Development.
- TERMINATED
- Registry status
- NA
- Development phase
- 9 participants
- Enrollment target
Study Summary
The purpose of this study is 1) to determine whether Imiquimod or Steroid pretreatment modifies UVB laser light response resulting in increased cell death compared to UVB laser light alone; 2) to determine if pretreatment of psoriatic lesions with Imiquimod or Steroid prior to UVB laser light exposure selectively effects various T cell functions; 3) to determine clinical results from the Imiquimod/Steroid/UVB laser light and correlate those changes with immuno-histochemical changes in the skin; and 4) to determine if single high dose lesion limited UVB laser light intervention combined with Imiquimod or Steroid influences T cell changes
Primary Outcome
Lesions were treated with either Imiquimod or Clobetasol cream. Lesions were subsequently treated with UVB and biopsied. From the biopsy samples obtained from the Imiquimod arm, quantitative PCR was performed to measure levels of Myx A, an imiquimod response gene.
Interventions
- DRUG Imiquimod
- DRUG Clobetasol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2007-05 |
| Est. Completion | 2012-07 |
| Phase | NA |
Why NCT00470392 stopped before completion
NCT00470392 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Imiquimod is the first listed.
NCT00470392 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00470392 about?
NCT00470392 is a clinical study titled "Mechanistically-based Optimization of UV Radiation Therapy in Psoriasis". The purpose of this study is 1) to determine whether Imiquimod or Steroid pretreatment modifies UVB laser light response resulting in increased cell death compared to UVB laser light alone; 2) to determine if pretreatment of psoriatic lesions with Imiquimod or Steroid prior to UVB laser light exposu...
What is the current status of trial NCT00470392?
This trial is currently terminated. It is a NA study. The enrollment target is 9 participants. The study started on 2007-05. Estimated completion is 2012-07.
What interventions are being tested in trial NCT00470392?
The interventions under investigation include: Imiquimod (DRUG), Clobetasol (DRUG).
Who is sponsoring clinical trial NCT00470392?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00470392's enrollment target sits among peer trials
9 1975th of 2000 higher than 25 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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