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NCT00469937 · ClinicalTrials.gov registry record · Phase 1
Ph I Study of Lithium During Whole Brain Radiotherapy For Patients With Brain Metastases
A Phase 1 study, sponsored by Vanderbilt-Ingram Cancer Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
NCT00469937: Clinical Trial Phase 1 study, sponsored by Vanderbilt-Ingram Cancer Center.
NCT00469937 is a Phase 1 study that was terminated before completion, run by Vanderbilt-Ingram Cancer Center. The registered enrollment target is 9 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00469937, a Phase 1 study, was terminated before completion, sponsored by Vanderbilt-Ingram Cancer Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
Study Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as lithium, may protect normal cells from the side effects of radiation therapy. Giving lithium together with radiation therapy may allow a higher dose of radiation therapy to be given so that more tumor cells are killed. PURPOSE: This phase I trial is studying the side effects and best dose of lithium when given together with whole-brain radiation therapy in treating patients with brain metastases from primary cancer outside the brain.
Interventions
- PROCEDURE quality-of-life assessment
- RADIATION radiation therapy
- PROCEDURE cognitive assessment
- DRUG lithium carbonate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2006-02 |
| Est. Completion | 2009-03 |
| Phase | Phase 1 |
Why NCT00469937 stopped before completion
NCT00469937 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 4 interventions - of which quality-of-life assessment is the first listed.
NCT00469937 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00469937 about?
NCT00469937 is a clinical study titled "Ph I Study of Lithium During Whole Brain Radiotherapy For Patients With Brain Metastases". RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as lithium, may protect normal cells from the side effects of radiation therapy. Giving lithium together with radiation therapy may allow a higher dose of radiation therapy to be given so that more tumor cells are ...
What is the current status of trial NCT00469937?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2006-02. Estimated completion is 2009-03.
What interventions are being tested in trial NCT00469937?
The interventions under investigation include: quality-of-life assessment (PROCEDURE), radiation therapy (RADIATION), cognitive assessment (PROCEDURE), lithium carbonate (DRUG).
Who is sponsoring clinical trial NCT00469937?
This trial is sponsored by Vanderbilt-Ingram Cancer Center, which has 189 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00469937's enrollment target sits among peer trials
9 1955th of 2000 higher than 42 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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