Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00469274 · ClinicalTrials.gov registry record · NA
Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure
A NA study, sponsored by Vanderbilt University.
- Completed
- Registry status
- NA
- Development phase
- 1,102
- Enrollment target
NCT00469274: Completed NA study, sponsored by Vanderbilt University.
NCT00469274 is a NA study that has completed, run by Vanderbilt University. The registered enrollment target is 1,102 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (22% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00469274, a NA study, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- NA
- Development phase
- 1,102 participants
- Enrollment target
Study Summary
The purpose of this study is to compare the effectiveness of two strategies of post-exposure prophylaxis (PEP) in healthcare workers (HCWs) who have been vaccinated with acellular pertussis vaccine and have been exposed to pertussis Secondary Objectives include a comparison of the costs of each PEP strategy and an assessment for risk factors associated with healthcare-associated acquisition of pertussis.
Primary Outcome
Defined as a positive nasopharyngeal culture or PCR for B. pertussis at any time point, a two-fold rise in the anti-PT IgG titer between acute and convalescent sera, or a single acute or convalescent anti-PT IgG titer of ≥94 EU. Post hoc, a modified definition was devised because of concern that the serologic criteria used in the primary definition might actually represent acquisition of pertussis infection prior to the intervention. The modified definition of pertussis excluded an acute anti-PT
Interventions
- DRUG Antibiotic PEP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,102 participants |
| Start Date | 2007-05 |
| Est. Completion | 2009-12 |
| Phase | NA |
What the finished NCT00469274 record still lists
NCT00469274 is an interventional study that assigns participants to a tested intervention. Its 1,102 participants enrollment target places it among the larger protocols in the corpus, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (22% lower).
The record links to 0 conditions, and to 1 intervention - of which Antibiotic PEP is the first listed.
NCT00469274 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00469274 about?
NCT00469274 is a clinical study titled "Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure". The purpose of this study is to compare the effectiveness of two strategies of post-exposure prophylaxis (PEP) in healthcare workers (HCWs) who have been vaccinated with acellular pertussis vaccine and have been exposed to pertussis Secondary Objectives include a comparison of the costs of each PEP ...
What is the current status of trial NCT00469274?
This trial is currently completed. It is a NA study. The enrollment target is 1,102 participants. The study started on 2007-05. Estimated completion is 2009-12.
What interventions are being tested in trial NCT00469274?
The interventions under investigation include: Antibiotic PEP (DRUG).
Who is sponsoring clinical trial NCT00469274?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00469274's enrollment target sits among peer trials
1,102 93rd of 2000 higher than 1,908 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00710112 · 1,100 participants
Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants
- NCT02688517 · 1,100 participants
Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer
- NCT04743765 · 1,100 participants · NA
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
- NCT05638581 · 1,100 participants · Phase 3
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia