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NCT00458575 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Safety of CNTO 2476 in Patients With Advanced Retinitis Pigmentosa
A Phase 1 study, sponsored by Centocor.
- Terminated
- Registry status
- Phase 1
- Development phase
- 7
- Enrollment target
NCT00458575: Clinical Trial Phase 1 study, sponsored by Centocor.
NCT00458575 is a Phase 1 study that was terminated before completion, run by Centocor. The registered enrollment target is 7 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (88% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00458575, a Phase 1 study, was terminated before completion, sponsored by Centocor.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 7 participants
- Enrollment target
Study Summary
The main purpose of this study is to evaluate the preliminary safety and immunogenicity (ability of an antigen to provoke immune response in the human body) of CNTO 2476, administered subretinally, in participants with advanced retinitis pigmentosa (RP; disease of the eye that leads to loss of vision and blindness) with either light perception only (LP) or hand motion (HM).
Interventions
- DRUG CNTO 2476
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2007-04 |
| Est. Completion | 2013-08 |
| Phase | Phase 1 |
Why NCT00458575 stopped before completion
NCT00458575 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (88% lower).
The record links to 0 conditions, and to 1 intervention - of which CNTO 2476 is the first listed.
NCT00458575 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00458575 about?
NCT00458575 is a clinical study titled "A Study to Evaluate the Safety of CNTO 2476 in Patients With Advanced Retinitis Pigmentosa". The main purpose of this study is to evaluate the preliminary safety and immunogenicity (ability of an antigen to provoke immune response in the human body) of CNTO 2476, administered subretinally, in participants with advanced retinitis pigmentosa (RP; disease of the eye that leads to loss of visio...
What is the current status of trial NCT00458575?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 7 participants. The study started on 2007-04. Estimated completion is 2013-08.
What interventions are being tested in trial NCT00458575?
The interventions under investigation include: CNTO 2476 (DRUG).
Who is sponsoring clinical trial NCT00458575?
This trial is sponsored by Centocor, which has 33 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00458575's enrollment target sits among peer trials
7 1972nd of 2000 higher than 27 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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