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NCT00439270 · ClinicalTrials.gov registry record · Phase 1
Study of Dasatinib and Docetaxel in Metastatic Hormone Refractory Prostate Cancer
A Phase 1 study, sponsored by Bristol-Myers Squibb.
- Completed
- Registry status
- Phase 1
- Development phase
- 49
- Enrollment target
NCT00439270: Completed Phase 1 study, sponsored by Bristol-Myers Squibb.
NCT00439270 is a Phase 1 study that has completed, run by Bristol-Myers Squibb. The registered enrollment target is 49 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (18% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00439270, a Phase 1 study, has completed, sponsored by Bristol-Myers Squibb.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 49 participants
- Enrollment target
Study Summary
The purpose of this study is to find the recommended doses of dasatinib and docetaxel given in combination to men with metastatic hormone refractory prostate cancer and to assess the pharmacokinetic interactions between the 2 drugs.
Primary Outcome
MTD was defined by dose-limiting toxicity (DLT) criteria. DLT was defined as grade 4 neutropenia causing treatment interruption for \>14 days, febrile neutropenia, grade 4 thrombocytopenia, grade 3 thrombocytopenia with a bleeding episode requiring platelet transfusion, nausea and/or vomiting despite medical intervention/prophylaxis causing treatment interruption for \>14 days, grade 3-4 asthenia/fatigue, any other grade \>=3 nonhematologic toxicity except alopecia or transient arthralgia/myalgi
Interventions
- DRUG Docetaxel
- DRUG Dasatinib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 49 participants |
| Start Date | 2007-07 |
| Est. Completion | 2013-01 |
| Phase | Phase 1 |
What the finished NCT00439270 record still lists
NCT00439270 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 49 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (18% lower).
The record links to 0 conditions, and to 2 interventions - of which Docetaxel is the first listed.
NCT00439270 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00439270 about?
NCT00439270 is a clinical study titled "Study of Dasatinib and Docetaxel in Metastatic Hormone Refractory Prostate Cancer". The purpose of this study is to find the recommended doses of dasatinib and docetaxel given in combination to men with metastatic hormone refractory prostate cancer and to assess the pharmacokinetic interactions between the 2 drugs.
What is the current status of trial NCT00439270?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 49 participants. The study started on 2007-07. Estimated completion is 2013-01.
What interventions are being tested in trial NCT00439270?
The interventions under investigation include: Docetaxel (DRUG), Dasatinib (DRUG).
Who is sponsoring clinical trial NCT00439270?
This trial is sponsored by Bristol-Myers Squibb, which has 1,025 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00439270's enrollment target sits among peer trials
49 1017th of 2000 higher than 976 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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