Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00438321 · ClinicalTrials.gov registry record · Phase 1
Effect of Increasing Testosterone on Insulin Sensitivity in Men With the Metabolic Syndrome
A Phase 1 study, sponsored by Massachusetts General Hospital.
- Terminated
- Registry status
- Phase 1
- Development phase
- 66
- Enrollment target
NCT00438321: Clinical Trial Phase 1 study, sponsored by Massachusetts General Hospital.
NCT00438321 is a Phase 1 study that was terminated before completion, run by Massachusetts General Hospital. The registered enrollment target is 66 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (10% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00438321, a Phase 1 study, was terminated before completion, sponsored by Massachusetts General Hospital.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 66 participants
- Enrollment target
Study Summary
The purpose of the study is to examine the effect of testosterone treatment on insulin in men with the metabolic syndrome with testosterone levels at or below the lower end of the normal range.
Primary Outcome
Assessed by euglycemic-hyperinsulinemic clamp
Interventions
- OTHER Placebo
- DRUG Zoladex
- DRUG Testosterone gel
- DRUG Anastrozole Pill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2006-09 |
| Est. Completion | 2010-02-26 |
| Phase | Phase 1 |
Why NCT00438321 stopped before completion
NCT00438321 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (10% higher).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT00438321 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00438321 about?
NCT00438321 is a clinical study titled "Effect of Increasing Testosterone on Insulin Sensitivity in Men With the Metabolic Syndrome". The purpose of the study is to examine the effect of testosterone treatment on insulin in men with the metabolic syndrome with testosterone levels at or below the lower end of the normal range.
What is the current status of trial NCT00438321?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 66 participants. The study started on 2006-09. Estimated completion is 2010-02-26.
What interventions are being tested in trial NCT00438321?
The interventions under investigation include: Placebo (OTHER), Zoladex (DRUG), Testosterone gel (DRUG), Anastrozole Pill (DRUG).
Who is sponsoring clinical trial NCT00438321?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00438321's enrollment target sits among peer trials
66 786th of 2000 higher than 1,203 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02584244 · 66 participants · Phase 1
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
- NCT03067051 · 66 participants · Phase 1
Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
- NCT03754725 · 66 participants · Phase 1
Ferritin and Iron Burden in SAH sIRB
- NCT03875378 · 66 participants · Phase 2
Transdermal Estrogen in Women With Anorexia Nervosa
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia