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NCT00434005 · ClinicalTrials.gov registry record · NA
Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans
A NA study, sponsored by University of Washington.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
NCT00434005 is a NA study that has completed, run by University of Washington. The registered enrollment target is 24 participants.
The verdict
NCT00434005, a NA study, has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
Study Summary
Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. This project will use a controlled human inhalation exposure to diesel exhaust particulate (DEP) as a model to address the following objectives: 1) Determine whether exposure to inhaled DEP is associated with endothelial dysfunction in a concentration-related manner; 2) Determine whether exposure to inhaled DEP is associated with evidence of systemic oxidative stress; and 3) Determine whether antioxidant supplementation blunts the DEP effect on endothelial function.
Interventions
- DRUG Placebo
- DRUG N-acetylcysteine, ascorbate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2008-07 |
| Est. Completion | 2010-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00434005
The ClinicalTrials.gov registry entry for NCT00434005 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Washington, which has 1,048 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00434005 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00434005 about?
NCT00434005 is a clinical study titled "Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans". Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. This project will use a controlled human inhalation exposure to diesel exh...
What is the current status of trial NCT00434005?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2008-07. Estimated completion is 2010-08.
What interventions are being tested in trial NCT00434005?
The interventions under investigation include: Placebo (DRUG), N-acetylcysteine, ascorbate (DRUG).
Who is sponsoring clinical trial NCT00434005?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
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