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NCT00434005 · ClinicalTrials.gov registry record · NA
Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans
A NA study, sponsored by University of Washington.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
NCT00434005: Completed NA study, sponsored by University of Washington.
NCT00434005 is a NA study that has completed, run by University of Washington. The registered enrollment target is 24 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00434005, a NA study, has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
Study Summary
Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. This project will use a controlled human inhalation exposure to diesel exhaust particulate (DEP) as a model to address the following objectives: 1) Determine whether exposure to inhaled DEP is associated with endothelial dysfunction in a concentration-related manner; 2) Determine whether exposure to inhaled DEP is associated with evidence of systemic oxidative stress; and 3) Determine whether antioxidant supplementation blunts the DEP effect on endothelial function.
Interventions
- DRUG Placebo
- DRUG N-acetylcysteine, ascorbate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2008-07 |
| Est. Completion | 2010-08 |
| Phase | NA |
What the finished NCT00434005 record still lists
NCT00434005 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00434005 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00434005 about?
NCT00434005 is a clinical study titled "Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans". Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. This project will use a controlled human inhalation exposure to diesel exh...
What is the current status of trial NCT00434005?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2008-07. Estimated completion is 2010-08.
What interventions are being tested in trial NCT00434005?
The interventions under investigation include: Placebo (DRUG), N-acetylcysteine, ascorbate (DRUG).
Who is sponsoring clinical trial NCT00434005?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00434005's enrollment target sits among peer trials
24 1736th of 2000 higher than 246 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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