Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00432445 · ClinicalTrials.gov registry record · Phase 2
Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma
A Phase 2 study, sponsored by M.D. Anderson Cancer Center.
- Terminated
- Registry status
- Phase 2
- Development phase
- 2
- Enrollment target
NCT00432445: Clinical Trial Phase 2 study, sponsored by M.D. Anderson Cancer Center.
NCT00432445 is a Phase 2 study that was terminated before completion, run by M.D. Anderson Cancer Center. The registered enrollment target is 2 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00432445, a Phase 2 study, was terminated before completion, sponsored by M.D. Anderson Cancer Center.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 2 participants
- Enrollment target
Study Summary
The purpose of this trial is to evaluate proton beam radiation therapy as an alternative to external photon beam irradiation in children with retinoblastoma as a means of local tumor control and ocular retention.
Primary Outcome
Where proton beam radiation therapy used as an alternative to external photon beam irradiation in children with retinoblastoma as a means of local tumor control and ocular retention, local tumor control measured for participants with a globe as tumor regression with ocular retention, and for post enucleation measured as lack of orbital tumor recurrence.
Interventions
- RADIATION Proton Beam Radiation Therapy
- PROCEDURE Ophthalmic EUA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2007-01 |
| Est. Completion | 2014-02 |
| Phase | Phase 2 |
Why NCT00432445 stopped before completion
NCT00432445 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Proton Beam Radiation Therapy is the first listed.
NCT00432445 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00432445 about?
NCT00432445 is a clinical study titled "Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma". The purpose of this trial is to evaluate proton beam radiation therapy as an alternative to external photon beam irradiation in children with retinoblastoma as a means of local tumor control and ocular retention.
What is the current status of trial NCT00432445?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 2 participants. The study started on 2007-01. Estimated completion is 2014-02.
What interventions are being tested in trial NCT00432445?
The interventions under investigation include: Proton Beam Radiation Therapy (RADIATION), Ophthalmic EUA (PROCEDURE).
Who is sponsoring clinical trial NCT00432445?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00432445's enrollment target sits among peer trials
2 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia