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NCT00429364 · ClinicalTrials.gov registry record · Phase 3
Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome
A Phase 3 study, sponsored by Carelon Research.
- Completed
- Registry status
- Phase 3
- Development phase
- 608
- Enrollment target
NCT00429364: Completed Phase 3 study, sponsored by Carelon Research.
NCT00429364 is a Phase 3 study that has completed, run by Carelon Research. The registered enrollment target is 608 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (21% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00429364, a Phase 3 study, has completed, sponsored by Carelon Research.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 608 participants
- Enrollment target
Study Summary
Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities. This study will compare the effectiveness of two medications, losartan and atenolol, at slowing aortic root enlargement in individuals with Marfan syndrome.
Primary Outcome
The rate of aortic root enlargement, expressed as the annual change in the maximum aortic-root-diameter z score indexed to body-surface area over a 3-year period following randomization
Interventions
- DRUG Atenolol
- DRUG Losartan Potassium
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 608 participants |
| Start Date | 2007-01 |
| Est. Completion | 2014-02 |
| Phase | Phase 3 |
What the finished NCT00429364 record still lists
NCT00429364 is an interventional study that assigns participants to a tested intervention. The registered 608 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (21% lower).
The record links to 0 conditions, and to 2 interventions - of which Atenolol is the first listed.
NCT00429364 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00429364 about?
NCT00429364 is a clinical study titled "Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome". Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities. This study will compare the effectiveness of two medications, losartan and atenolol, at slowing aortic root enlargement in individuals ...
What is the current status of trial NCT00429364?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 608 participants. The study started on 2007-01. Estimated completion is 2014-02.
What interventions are being tested in trial NCT00429364?
The interventions under investigation include: Atenolol (DRUG), Losartan Potassium (DRUG).
Who is sponsoring clinical trial NCT00429364?
This trial is sponsored by Carelon Research, which has 50 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00429364's enrollment target sits among peer trials
608 603rd of 2000 higher than 1,396 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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