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NCT00427336 · ClinicalTrials.gov registry record · NA
Purine Analog-Based Conditioning in Patients With Severe Aplastic Anemia
A NA study, sponsored by M.D. Anderson Cancer Center.
- Completed
- Registry status
- NA
- Development phase
- 9
- Enrollment target
NCT00427336: Completed NA study, sponsored by M.D. Anderson Cancer Center.
NCT00427336 is a NA study that has completed, run by M.D. Anderson Cancer Center. The registered enrollment target is 9 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00427336, a NA study, has completed, sponsored by M.D. Anderson Cancer Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 9 participants
- Enrollment target
Study Summary
Primary Objectives: 1. To determine the feasibility and toxicity of employing purine-analog based conditioning for allogeneic donor stem cell transplantation in patients with severe aplastic anemia (AA). 2. To determine the engraftment kinetics and degree of chimerism that can be achieved with this strategy.
Primary Outcome
Engraftment defined as (1) the first of three consecutive days of an Absolute neutrophil count (ANC) \>500/mL (b) the first of seven consecutive days of an unsupported platelet count 20,000. Patient needs to survive at least 28 days to be evaluable for engraftment. Chimerism studies need to demonstrate donor-derived hematopoiesis (\>90%)
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG Antithymocyte Globulin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2000-12 |
| Est. Completion | 2009-08 |
| Phase | NA |
What the finished NCT00427336 record still lists
NCT00427336 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Cyclophosphamide is the first listed.
NCT00427336 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00427336 about?
NCT00427336 is a clinical study titled "Purine Analog-Based Conditioning in Patients With Severe Aplastic Anemia". Primary Objectives: 1. To determine the feasibility and toxicity of employing purine-analog based conditioning for allogeneic donor stem cell transplantation in patients with severe aplastic anemia (AA). 2. To determine the engraftment kinetics and degree of chimerism that can be achieved with this...
What is the current status of trial NCT00427336?
This trial is currently completed. It is a NA study. The enrollment target is 9 participants. The study started on 2000-12. Estimated completion is 2009-08.
What interventions are being tested in trial NCT00427336?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Antithymocyte Globulin (DRUG).
Who is sponsoring clinical trial NCT00427336?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00427336's enrollment target sits among peer trials
9 1975th of 2000 higher than 25 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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