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NCT00424242 · ClinicalTrials.gov registry record · Early Phase 1
Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases
A Early Phase 1 study, sponsored by Northwestern University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 15
- Enrollment target
NCT00424242: Completed Early Phase 1 study, sponsored by Northwestern University.
NCT00424242 is a Early Phase 1 study that has completed, run by Northwestern University. The registered enrollment target is 15 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (72% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00424242, a Early Phase 1 study, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 15 participants
- Enrollment target
Study Summary
RATIONALE: Pemetrexed disodium may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Studying samples of cerebrospinal fluid and blood from patients with cancer in the laboratory may help doctors learn how pemetrexed disodium works in the body and identify biomarkers related to cancer. PURPOSE: This clinical trial is studying the side effects and how well pemetrexed disodium works in treating patients with leptomeningeal metastases.
Primary Outcome
Patients will have CSF collected approximately every 6 weeks for assessment while on study.
Interventions
- DRUG Pemetrexed
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2007-01 |
| Est. Completion | 2011-09 |
| Phase | Early Phase 1 |
What the finished NCT00424242 record still lists
NCT00424242 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (72% lower).
The record links to 0 conditions, and to 1 intervention - of which Pemetrexed is the first listed.
NCT00424242 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00424242 about?
NCT00424242 is a clinical study titled "Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases". RATIONALE: Pemetrexed disodium may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Studying samples of cerebrospinal fluid and blood from patients with cancer in the laboratory may help doctors learn how pemetrexed disodium works in the body and identify bioma...
What is the current status of trial NCT00424242?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 15 participants. The study started on 2007-01. Estimated completion is 2011-09.
What interventions are being tested in trial NCT00424242?
The interventions under investigation include: Pemetrexed (DRUG).
Who is sponsoring clinical trial NCT00424242?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00424242's enrollment target sits among peer trials
15 1404th of 2000 higher than 527 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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