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NCT00407381 · ClinicalTrials.gov registry record · Phase 2
The Ranibizumab for Edema of the mAcula in Diabetes-2 (READ-2) Study
A Phase 2 study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 2
- Development phase
- 126
- Enrollment target
NCT00407381: Completed Phase 2 study, sponsored by Johns Hopkins University.
NCT00407381 is a Phase 2 study that has completed, run by Johns Hopkins University. The registered enrollment target is 126 participants, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00407381, a Phase 2 study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 126 participants
- Enrollment target
Study Summary
This study is being done to see if the investigational drug Ranibizumab (RBZ) given by injection into the eye, is safe and effective to use in people with diabetic macular edema (DME). The investigators want to compare RBZ to laser treatment which is the current standard way to treat DME. RBZ blocks a growth factor that is thought to be involved in the formation of abnormal blood vessels that cause loss of vision in patients with DME.
Primary Outcome
Mean change of best corrected visual acuity letters (BCVA) at month 6
Interventions
- DRUG Ranibizumab
- PROCEDURE Laser photocoagulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2006-12 |
| Est. Completion | 2011-08 |
| Phase | Phase 2 |
What the finished NCT00407381 record still lists
NCT00407381 is an interventional study that assigns participants to a tested intervention. The registered 126 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target.
The record links to 0 conditions, and to 2 interventions - of which Ranibizumab is the first listed.
NCT00407381 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00407381 about?
NCT00407381 is a clinical study titled "The Ranibizumab for Edema of the mAcula in Diabetes-2 (READ-2) Study". This study is being done to see if the investigational drug Ranibizumab (RBZ) given by injection into the eye, is safe and effective to use in people with diabetic macular edema (DME). The investigators want to compare RBZ to laser treatment which is the current standard way to treat DME. RBZ block...
What is the current status of trial NCT00407381?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 126 participants. The study started on 2006-12. Estimated completion is 2011-08.
What interventions are being tested in trial NCT00407381?
The interventions under investigation include: Ranibizumab (DRUG), Laser photocoagulation (PROCEDURE).
Who is sponsoring clinical trial NCT00407381?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00407381's enrollment target sits among peer trials
126 556th of 2000 higher than 1,443 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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