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NCT00405951 · ClinicalTrials.gov registry record · Phase 1
Safety and Efficacy of Obatoclax Mesylate (GX15-070MS)in Combination With Docetaxel for the Treatment of Non-Small Cell Lung Cancer
A Phase 1 study, sponsored by Gemin X.
- Completed
- Registry status
- Phase 1
- Development phase
- 47
- Enrollment target
NCT00405951 is a Phase 1 study that has completed, run by Gemin X. The registered enrollment target is 47 participants.
The verdict
NCT00405951, a Phase 1 study, has completed, sponsored by Gemin X.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 47 participants
- Enrollment target
Study Summary
Defects in the apoptotic process can lead to the onset of cancer by allowing cells to grow unchecked when an oncogneic signal is present. Obatoclax is designed to restore apoptosis through inhibition of the Bcl-2 family of proteins, thereby reinstating the natural process of cell death that is often inhibited in cancer cells. This is a multi-center, open-label, Phase I/II study of obatoclax administered in combination with docetaxel in 3-week cycles to patients with relapsed or refractory Non-Small Cell Lung Cancer. Treatment may be administered on an outpatient basis. No investigation or commercial agents or therapies other than those described herein may be administered with the intent to treat the patient's malignancy. Supportive care measures including those directed at controlling symptoms resulting from Non-Small Cell Lung Cancer are allowed.
Interventions
- DRUG Docetaxel
- DRUG Obatoclax mesylate 250 ml
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 47 participants |
| Start Date | 2006-10 |
| Est. Completion | 2009-09 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00405951
The ClinicalTrials.gov registry entry for NCT00405951 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 47 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gemin X, which has 11 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Docetaxel is the first listed.
NCT00405951 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00405951 about?
NCT00405951 is a clinical study titled "Safety and Efficacy of Obatoclax Mesylate (GX15-070MS)in Combination With Docetaxel for the Treatment of Non-Small Cell Lung Cancer". Defects in the apoptotic process can lead to the onset of cancer by allowing cells to grow unchecked when an oncogneic signal is present. Obatoclax is designed to restore apoptosis through inhibition of the Bcl-2 family of proteins, thereby reinstating the natural process of cell death that is often...
What is the current status of trial NCT00405951?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 47 participants. The study started on 2006-10. Estimated completion is 2009-09.
What interventions are being tested in trial NCT00405951?
The interventions under investigation include: Docetaxel (DRUG), Obatoclax mesylate 250 ml (DRUG).
Who is sponsoring clinical trial NCT00405951?
This trial is sponsored by Gemin X, which has 11 total clinical trials registered on ClinicalTrials.gov.
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