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NCT00385216 · ClinicalTrials.gov registry record · Phase 4
Nicotine as an Adjuvant Analgesic for Third Molar Surgery
A Phase 4 study, sponsored by Columbia University.
- Completed
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
NCT00385216: Completed Phase 4 study, sponsored by Columbia University.
NCT00385216 is a Phase 4 study that has completed, run by Columbia University. The registered enrollment target is 20 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00385216, a Phase 4 study, has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
Study Summary
Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.
Primary Outcome
Pain were reported on the numerical rating scale for pain (NRS) with 0=no pain and 10=worst pain.
Interventions
- OTHER Placebo
- DRUG Nicotine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2004-07 |
| Est. Completion | 2009-06 |
| Phase | Phase 4 |
What the finished NCT00385216 record still lists
NCT00385216 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00385216 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00385216 about?
NCT00385216 is a clinical study titled "Nicotine as an Adjuvant Analgesic for Third Molar Surgery". Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray befor...
What is the current status of trial NCT00385216?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2004-07. Estimated completion is 2009-06.
What interventions are being tested in trial NCT00385216?
The interventions under investigation include: Placebo (OTHER), Nicotine (DRUG).
Who is sponsoring clinical trial NCT00385216?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00385216's enrollment target sits among peer trials
20 1753rd of 2000 higher than 167 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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