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NCT00383630 · ClinicalTrials.gov registry record · Phase 2
Bone Marrow Cell Transplantation to Improve Heart Function in Individuals With End-Stage Heart Failure
A Phase 2 study, sponsored by Columbia University.
- Terminated
- Registry status
- Phase 2
- Development phase
- 1
- Enrollment target
NCT00383630: Clinical Trial Phase 2 study, sponsored by Columbia University.
NCT00383630 is a Phase 2 study that was terminated before completion, run by Columbia University. The registered enrollment target is 1 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00383630, a Phase 2 study, was terminated before completion, sponsored by Columbia University.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 1 participants
- Enrollment target
Study Summary
Heart failure is a condition in which the heart is unable to pump enough blood to the body's other organs. A heart transplant may be necessary for some individuals with end-stage heart failure. Left ventricular assist devices (LVADs) can assist the heart in pumping blood, and are commonly used until a donor heart becomes available. Bone marrow cells injected into the heart may improve heart function and may lead to earlier LVAD removal. The purpose of this study is to evaluate the safety and effectiveness of injected bone marrow cells in improving heart function in individuals with LVADs who are awaiting heart transplants.
Primary Outcome
This defines the functional status. Due to poor enrollment, data was not analyzed.
Interventions
- BIOLOGICAL Intramyocardial injection of bone marrow mononuclear cells
- BIOLOGICAL Intramyocardial injection of CD34+ selected bone marrow mononuclear cells
- DEVICE LVAD alone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2007-09 |
| Est. Completion | 2008-12 |
| Phase | Phase 2 |
Why NCT00383630 stopped before completion
NCT00383630 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Intramyocardial injection of bone marrow mononuclear cells is the first listed.
NCT00383630 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00383630 about?
NCT00383630 is a clinical study titled "Bone Marrow Cell Transplantation to Improve Heart Function in Individuals With End-Stage Heart Failure". Heart failure is a condition in which the heart is unable to pump enough blood to the body's other organs. A heart transplant may be necessary for some individuals with end-stage heart failure. Left ventricular assist devices (LVADs) can assist the heart in pumping blood, and are commonly used until...
What is the current status of trial NCT00383630?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 1 participants. The study started on 2007-09. Estimated completion is 2008-12.
What interventions are being tested in trial NCT00383630?
The interventions under investigation include: Intramyocardial injection of bone marrow mononuclear cells (BIOLOGICAL), Intramyocardial injection of CD34+ selected bone marrow mononuclear cells (BIOLOGICAL), LVAD alone (DEVICE).
Who is sponsoring clinical trial NCT00383630?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00383630's enrollment target sits among peer trials
1 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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