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NCT00376558 · ClinicalTrials.gov registry record · NA
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
A NA study, sponsored by New York State Psychiatric Institute.
- Completed
- Registry status
- NA
- Development phase
- 50
- Enrollment target
NCT00376558: Completed NA study, sponsored by New York State Psychiatric Institute.
NCT00376558 is a NA study that has completed, run by New York State Psychiatric Institute. The registered enrollment target is 50 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00376558, a NA study, has completed, sponsored by New York State Psychiatric Institute.
- COMPLETED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
Study Summary
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse treatment. This study will also determine whether patients who do respond to treatment will experience a recovery of dopamine function. This study includes free brain imaging and behavioral intervention. Compensation provided for the brain scans.
Primary Outcome
The relationship between Methylphenidate-induced Dopamine Release in the Striatum (Measured by Displacement of \[11C\]-Raclopride by Oral Methylphenidate) and Treatment Response (Measured Using Community Reinforcement Approach and Contingency Management) was studied. Dopamine Function was assessed by evaluation of endogenous Dopamine release over the course of treatment (i.e., at 3 months as compared to baseline). Endogenous Dopamine release is inversely related to the change in binding potentia
Interventions
- BEHAVIORAL Community Reinforcement Approach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2006-07 |
| Est. Completion | 2011-01 |
| Phase | NA |
What the finished NCT00376558 record still lists
NCT00376558 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Community Reinforcement Approach is the first listed.
NCT00376558 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00376558 about?
NCT00376558 is a clinical study titled "Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence". The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse treatment. This study will also determine whether patients who do respond to tr...
What is the current status of trial NCT00376558?
This trial is currently completed. It is a NA study. The enrollment target is 50 participants. The study started on 2006-07. Estimated completion is 2011-01.
What interventions are being tested in trial NCT00376558?
The interventions under investigation include: Community Reinforcement Approach (BEHAVIORAL).
Who is sponsoring clinical trial NCT00376558?
This trial is sponsored by New York State Psychiatric Institute, which has 364 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00376558's enrollment target sits among peer trials
50 1279th of 2000 higher than 622 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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