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NCT00376376 · ClinicalTrials.gov registry record · NA
Urinary Bactericidal Activity of 4 Doses of Levofloxacin Against Fluoroquinolone-Resistant E. Coli
A NA study, sponsored by Michigan State University.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT00376376: Completed NA study, sponsored by Michigan State University.
NCT00376376 is a NA study that has completed, run by Michigan State University. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00376376, a NA study, has completed, sponsored by Michigan State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
Single-dose studies of a fluoroquinolone are indicative of their antimicrobial activity since little accumulation occurs with multiple doses. Single-dose studies have been utilized to determine drug concentrations and time kill activity in serum, urine, and respiratory tissues. The purpose of this study is to evaluate the Urine Bactericidal Activity (UBA) of levofloxacin (250, 500, 750, and 1000 mg) against FQ-resistant, ESBL positive E. coli isolates. In addition, a susceptibility breakpoint concentration in the urine can also be established for each dose of levofloxacin. Furthermore, urine concentrations and serum pharmacokinetic parameters of levofloxacin can be determined.
Interventions
- DRUG levofloxacin at 250, 500, 750, and 1000 mg doses
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2006-09 |
| Est. Completion | 2006-11 |
| Phase | NA |
What the finished NCT00376376 record still lists
NCT00376376 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which levofloxacin at 250, 500, 750, and 1000 mg doses is the first listed.
NCT00376376 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00376376 about?
NCT00376376 is a clinical study titled "Urinary Bactericidal Activity of 4 Doses of Levofloxacin Against Fluoroquinolone-Resistant E. Coli". Single-dose studies of a fluoroquinolone are indicative of their antimicrobial activity since little accumulation occurs with multiple doses. Single-dose studies have been utilized to determine drug concentrations and time kill activity in serum, urine, and respiratory tissues. The purpose of this ...
What is the current status of trial NCT00376376?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2006-09. Estimated completion is 2006-11.
What interventions are being tested in trial NCT00376376?
The interventions under investigation include: levofloxacin at 250, 500, 750, and 1000 mg doses (DRUG).
Who is sponsoring clinical trial NCT00376376?
This trial is sponsored by Michigan State University, which has 120 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00376376's enrollment target sits among peer trials
10 1927th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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