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NCT00374075 · ClinicalTrials.gov registry record · Phase 1
Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy
A Phase 1 study, sponsored by University of Utah.
- Completed
- Registry status
- Phase 1
- Development phase
- 42
- Enrollment target
NCT00374075: Completed Phase 1 study, sponsored by University of Utah.
NCT00374075 is a Phase 1 study that has completed, run by University of Utah. The registered enrollment target is 42 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (30% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00374075, a Phase 1 study, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 42 participants
- Enrollment target
Study Summary
This is an open label phase I/II clinical trial to assess safety, tolerability and potential effect on SMN mRNA and protein in vivo of a compound in which preliminary evidence supports a potential effect on SMN levels in vitro.
Interventions
- DRUG Valproic Acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2003-09 |
| Est. Completion | 2006-02 |
| Phase | Phase 1 |
What the finished NCT00374075 record still lists
NCT00374075 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (30% lower).
The record links to 0 conditions, and to 1 intervention - of which Valproic Acid is the first listed.
NCT00374075 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00374075 about?
NCT00374075 is a clinical study titled "Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy". This is an open label phase I/II clinical trial to assess safety, tolerability and potential effect on SMN mRNA and protein in vivo of a compound in which preliminary evidence supports a potential effect on SMN levels in vitro.
What is the current status of trial NCT00374075?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2003-09. Estimated completion is 2006-02.
What interventions are being tested in trial NCT00374075?
The interventions under investigation include: Valproic Acid (DRUG).
Who is sponsoring clinical trial NCT00374075?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00374075's enrollment target sits among peer trials
42 1105th of 2000 higher than 876 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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