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NCT00347360 · ClinicalTrials.gov registry record · Phase 3
The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial
A Phase 3 study, sponsored by GlaxoSmithKline.
- Completed
- Registry status
- Phase 3
- Development phase
- 654
- Enrollment target
NCT00347360: Completed Phase 3 study, sponsored by GlaxoSmithKline.
NCT00347360 is a Phase 3 study that has completed, run by GlaxoSmithKline. The registered enrollment target is 654 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (15% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00347360, a Phase 3 study, has completed, sponsored by GlaxoSmithKline.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 654 participants
- Enrollment target
Study Summary
This is a randomized, double-blind, double-dummy, parallel group trial employing 15 cells of a 4x4 factorial design (no placebo)to compare the hypertensive effects in patients with Stage 1 and Stage 2 hypertension of carvedilol (20, 40 or 80 mg daily) alone, lisinopril (10, 20 or 40 mg daily) alone, and all combinations of the doses.
Primary Outcome
Ambulatory blood pressure monitoring (ABPM) was completed at Baseline and at the end of treatment/Week 6 or early withdrawal by standard electronic ABPM equipment worn by the subject for 24-hr of ambulatory activity. The 24 hr assessment period started at the time of the first reading and ended exactly 24 hr later on the following day. Data collected included mean diastolic blood pressure (DBP).
Interventions
- DRUG lisinopril
- DRUG carvedilol controlled release formulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 654 participants |
| Start Date | 2006-07 |
| Est. Completion | 2008-04 |
| Phase | Phase 3 |
What the finished NCT00347360 record still lists
NCT00347360 is an interventional study that assigns participants to a tested intervention. The registered 654 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (15% lower).
The record links to 0 conditions, and to 2 interventions - of which lisinopril is the first listed.
NCT00347360 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00347360 about?
NCT00347360 is a clinical study titled "The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial". This is a randomized, double-blind, double-dummy, parallel group trial employing 15 cells of a 4x4 factorial design (no placebo)to compare the hypertensive effects in patients with Stage 1 and Stage 2 hypertension of carvedilol (20, 40 or 80 mg daily) alone, lisinopril (10, 20 or 40 mg daily) alone,...
What is the current status of trial NCT00347360?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 654 participants. The study started on 2006-07. Estimated completion is 2008-04.
What interventions are being tested in trial NCT00347360?
The interventions under investigation include: lisinopril (DRUG), carvedilol controlled release formulation (DRUG).
Who is sponsoring clinical trial NCT00347360?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00347360's enrollment target sits among peer trials
654 567th of 2000 higher than 1,430 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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