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NCT00321945 · ClinicalTrials.gov registry record
A Retrospective Analysis of the Use of ACE-inhibitors and Angiotensin Receptor Blockers
A clinical trial, sponsored by Emory University.
- Completed
- Registry status
- 546
- Enrollment target
NCT00321945: Completed study, sponsored by Emory University.
NCT00321945 is a clinical trial that has completed, run by Emory University. The registered enrollment target is 546 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00321945 has completed, sponsored by Emory University.
- COMPLETED
- Registry status
- 546 participants
- Enrollment target
Study Summary
It is well known that atrial fibrillation (AF) and atrial flutter occur frequently after most types of cardiac surgeries.(1-4) Postoperative AF is associated with significant morbidity, longer hospital stay, and higher related costs. Currently, it is common procedure to premedicate patients with antiarrhythmic drugs for elective cardiac surgeries. Treatments such as beta blockers, Amiodarone, and electrical pacing are used to help prevent the morbidity associated with pot-operative AF.(5) Renin-angiotensin system (RAS) activation may contribute to AF. Several clinical trials have suggested that inhibitors of this system may reduce the incidence of AF.(6-12) Patients with AF are known to have increased levels of angiotensin converting enzyme (ACE) and some types of angiotensin receptors.(13-15) Data from animal studies performed by our group suggest that cardiac ACE overexpression may lead to arrhythmic ion channel changes.(16;17) Although not studied in this group yet, it would be reasonable to conclude that the use of ACE inhibitors and angiotensin receptor blockers (ARBs) would decrease the incidence of AF in post-operative patients, too
Interventions
- PROCEDURE ACE-Inhibitors and Angiotensin Receptor Blockers
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 546 participants |
| Start Date | 2005-12 |
| Est. Completion | 2009-10 |
What the finished NCT00321945 record still lists
NCT00321945 is an observational study that tracks outcomes without assigning an intervention. The registered 546 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which ACE-Inhibitors and Angiotensin Receptor Blockers is the first listed.
NCT00321945 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00321945 about?
NCT00321945 is a clinical study titled "A Retrospective Analysis of the Use of ACE-inhibitors and Angiotensin Receptor Blockers". It is well known that atrial fibrillation (AF) and atrial flutter occur frequently after most types of cardiac surgeries.(1-4) Postoperative AF is associated with significant morbidity, longer hospital stay, and higher related costs. Currently, it is common procedure to premedicate patients with ant...
What is the current status of trial NCT00321945?
This trial is currently completed. The enrollment target is 546 participants. The study started on 2005-12. Estimated completion is 2009-10.
What interventions are being tested in trial NCT00321945?
The interventions under investigation include: ACE-Inhibitors and Angiotensin Receptor Blockers (PROCEDURE).
Who is sponsoring clinical trial NCT00321945?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
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