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NCT00303251 · ClinicalTrials.gov registry record · Phase 1
Safety of TKI258 in Advanced/Metastatic Melanoma Subjects
A Phase 1 study, sponsored by Novartis Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 47
- Enrollment target
NCT00303251: Completed Phase 1 study, sponsored by Novartis Pharmaceuticals.
NCT00303251 is a Phase 1 study that has completed, run by Novartis Pharmaceuticals. The registered enrollment target is 47 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (22% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00303251, a Phase 1 study, has completed, sponsored by Novartis Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 47 participants
- Enrollment target
Study Summary
This study is an open-label, dose-escalating study to delineate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TKI258. Pharmacokinetics and pharmacodynamics will be performed on all subjects. The eligible subject population consists of subjects who have been diagnosed with locally advanced or metastatic melanoma that is refractory to standard therapy or for which no curative standard therapy exists.
Interventions
- DRUG TKI258
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 47 participants |
| Start Date | 2006-04 |
| Phase | Phase 1 |
What the finished NCT00303251 record still lists
NCT00303251 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 47 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (22% lower).
The record links to 0 conditions, and to 1 intervention - of which TKI258 is the first listed.
NCT00303251 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00303251 about?
NCT00303251 is a clinical study titled "Safety of TKI258 in Advanced/Metastatic Melanoma Subjects". This study is an open-label, dose-escalating study to delineate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TKI258. Pharmacokinetics and pharmacodynamics will be performed on all subjects. The eligible subject population consists of subjects who have been diagnosed with locally a...
What is the current status of trial NCT00303251?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 47 participants. The study started on 2006-04.
What interventions are being tested in trial NCT00303251?
The interventions under investigation include: TKI258 (DRUG).
Who is sponsoring clinical trial NCT00303251?
This trial is sponsored by Novartis Pharmaceuticals, which has 1,375 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00303251's enrollment target sits among peer trials
47 1053rd of 2000 higher than 943 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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