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NCT00288262 · ClinicalTrials.gov registry record · Phase 1
Melatonin Effects on Luteinizing Hormone
A Phase 1 study, sponsored by Scripps Health.
- Terminated
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT00288262: Clinical Trial Phase 1 study, sponsored by Scripps Health.
NCT00288262 is a Phase 1 study that was terminated before completion, run by Scripps Health. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00288262, a Phase 1 study, was terminated before completion, sponsored by Scripps Health.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
In many mammals, the duration of the nocturnal melatonin elevation regulates seasonal changes in reproductive hormones such as luteinizing hormone (LH). Melatonin's effects on human reproductive endocrinology are uncertain. It is thought that the same hypothalamic pulse generator may both trigger the pulsatile release of GnRH and LH and also cause hot flashes. Thus, if melatonin suppressed this pulse generator in postmenopausal women, it might moderate hot flashes. This clinical trial tested the hypothesis that melatonin could suppress LH and relieve hot flashes.
Interventions
- DRUG melatonin 0.5 mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2004-06 |
| Est. Completion | 2005-02 |
| Phase | Phase 1 |
Why NCT00288262 stopped before completion
NCT00288262 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 1 intervention - of which melatonin 0.5 mg is the first listed.
NCT00288262 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00288262 about?
NCT00288262 is a clinical study titled "Melatonin Effects on Luteinizing Hormone". In many mammals, the duration of the nocturnal melatonin elevation regulates seasonal changes in reproductive hormones such as luteinizing hormone (LH). Melatonin's effects on human reproductive endocrinology are uncertain. It is thought that the same hypothalamic pulse generator may both trigger th...
What is the current status of trial NCT00288262?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2004-06. Estimated completion is 2005-02.
What interventions are being tested in trial NCT00288262?
The interventions under investigation include: melatonin 0.5 mg (DRUG).
Who is sponsoring clinical trial NCT00288262?
This trial is sponsored by Scripps Health, which has 30 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00288262's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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