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NCT00281203 · ClinicalTrials.gov registry record
Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD
A clinical trial, sponsored by University of Michigan.
- Completed
- Registry status
- 32
- Enrollment target
NCT00281203: Completed study, sponsored by University of Michigan.
NCT00281203 is a clinical trial that has completed, run by University of Michigan. The registered enrollment target is 32 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00281203 has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- 32 participants
- Enrollment target
Study Summary
This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show abnormal responsiveness to bacterial and viral products. Specifically, the study will determine the dose-response characteristics of AMø for production of interleukin (IL)-6, IL-18, and IL-23 (pro-inflammatory cytokines) on stimulation by purified lipopolysaccharide, a synthetic lipopeptide (PAM3-Cys), or poly I:C. These stimuli mimic the response to Gram-negative bacteria, Gram-positive bacteria, and RNA viruses, respectively. Results of the AMø from these healthy volunteers will be compared with AMø of COPD patients and smokers (or ex-smokers) with normal pulmonary function; those samples are being obtained during clinically indicated bronchoscopies under a separate consent form.
Interventions
- PROCEDURE blood drawing
- PROCEDURE fiberoptic bronchoscopy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2005-09 |
| Est. Completion | 2010-07 |
What the finished NCT00281203 record still lists
NCT00281203 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 32 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which blood drawing is the first listed.
NCT00281203 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00281203 about?
NCT00281203 is a clinical study titled "Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD". This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show abnormal responsiveness to bacterial and viral products. Specifically, the study will determine the...
What is the current status of trial NCT00281203?
This trial is currently completed. The enrollment target is 32 participants. The study started on 2005-09. Estimated completion is 2010-07.
What interventions are being tested in trial NCT00281203?
The interventions under investigation include: blood drawing (PROCEDURE), fiberoptic bronchoscopy (PROCEDURE).
Who is sponsoring clinical trial NCT00281203?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
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