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NCT00277446 · ClinicalTrials.gov registry record · NA
Dietary Supplementation With Soy Isoflavones in Asthma
A NA study, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 13
- Enrollment target
NCT00277446 is a NA study that has completed, run by Northwestern University. The registered enrollment target is 13 participants.
The verdict
NCT00277446, a NA study, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 13 participants
- Enrollment target
Study Summary
An epidemiologic study of patients with asthma has shown that increased intake of soy isoflavones correlates with less severe asthma. In experimental animals, treatment with the soy isoflavone genistein reduces airways inflammation and hyper-responsiveness. In vitro studies performed by us have shows that genistein reduces release of inflammatory compounds by human blood eosinophils. The purpose of this pilot study is to determine whether dietary supplementation with soy isoflavones has effects in patients with asthma. 20 patients with asthma will supplement their diet with a soy isoflavone capsule for 4 weeks. Before and after the supplementation period, we will measure lung function, exhaled nitric oxide (a marker for airway inflammation), collect exhaled breath condensate to measure levels of inflammatory mediators in the airways, and isolate peripheral blood eosinophils to assess the impact of soy isoflavones on their function. We hypothesize that dietary supplementation with soy isoflavones will reduce exhaled nitric oxide level, reduce the inflammatory mediators in the exhaled breath condensate, and reduce the ability of eosinophils to release inflammatory molecules. Identifying if these hypothesized effects of soy isoflavones exist in asthma will provide a justification for further clinical studies.
Interventions
- DRUG Soy isoflavones
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2006-01 |
| Est. Completion | 2007-04 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00277446
The ClinicalTrials.gov registry entry for NCT00277446 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 13 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Soy isoflavones is the first listed.
NCT00277446 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00277446 about?
NCT00277446 is a clinical study titled "Dietary Supplementation With Soy Isoflavones in Asthma". An epidemiologic study of patients with asthma has shown that increased intake of soy isoflavones correlates with less severe asthma. In experimental animals, treatment with the soy isoflavone genistein reduces airways inflammation and hyper-responsiveness. In vitro studies performed by us have show...
What is the current status of trial NCT00277446?
This trial is currently completed. It is a NA study. The enrollment target is 13 participants. The study started on 2006-01. Estimated completion is 2007-04.
What interventions are being tested in trial NCT00277446?
The interventions under investigation include: Soy isoflavones (DRUG).
Who is sponsoring clinical trial NCT00277446?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
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