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NCT00274391 · ClinicalTrials.gov registry record · Phase 2
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
A Phase 2 study, sponsored by University of North Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 24
- Enrollment target
NCT00274391 is a Phase 2 study that has completed, run by University of North Carolina. The registered enrollment target is 24 participants.
The verdict
NCT00274391, a Phase 2 study, has completed, sponsored by University of North Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 24 participants
- Enrollment target
Study Summary
The purpose of this research study is to determine whether the combination of inhaled amiloride and a concentrated salt solution is better than the salt solution itself for cystic fibrosis (CF) patients. In CF, airway secretions are thick and dehydrated. Many patients use inhaled salt solutions to help draw water into their secretions so that they are easier to get rid of with chest physiotherapy ("chest PT") and cough. Unfortunately, these salt solutions are reabsorbed very quickly by the airways, so the beneficial effects may not last very long. In the hopes of prolonging their effects, the drug amiloride could be used in combination to slow salt and water reabsorption from airways. Amiloride is a medication that has been given by mouth for high blood pressure for many years. It is possible that the combination of salt solutions and inhaled amiloride may significantly improve the clearance of secretions in CF, which would be expected to improve lung function in CF.
Interventions
- DRUG 7% NaCl
- DRUG Amiloride HCl
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2001-07 |
| Est. Completion | 2004-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00274391
The ClinicalTrials.gov registry entry for NCT00274391 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of North Carolina, which has 14 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which 7% NaCl is the first listed.
NCT00274391 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00274391 about?
NCT00274391 is a clinical study titled "Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis". The purpose of this research study is to determine whether the combination of inhaled amiloride and a concentrated salt solution is better than the salt solution itself for cystic fibrosis (CF) patients. In CF, airway secretions are thick and dehydrated. Many patients use inhaled salt solutions to h...
What is the current status of trial NCT00274391?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2001-07. Estimated completion is 2004-04.
What interventions are being tested in trial NCT00274391?
The interventions under investigation include: 7% NaCl (DRUG), Amiloride HCl (DRUG).
Who is sponsoring clinical trial NCT00274391?
This trial is sponsored by University of North Carolina, which has 14 total clinical trials registered on ClinicalTrials.gov.
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