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NCT00274391 · ClinicalTrials.gov registry record · Phase 2
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
A Phase 2 study, sponsored by University of North Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 24
- Enrollment target
NCT00274391: Completed Phase 2 study, sponsored by University of North Carolina.
NCT00274391 is a Phase 2 study that has completed, run by University of North Carolina. The registered enrollment target is 24 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00274391, a Phase 2 study, has completed, sponsored by University of North Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 24 participants
- Enrollment target
Study Summary
The purpose of this research study is to determine whether the combination of inhaled amiloride and a concentrated salt solution is better than the salt solution itself for cystic fibrosis (CF) patients. In CF, airway secretions are thick and dehydrated. Many patients use inhaled salt solutions to help draw water into their secretions so that they are easier to get rid of with chest physiotherapy ("chest PT") and cough. Unfortunately, these salt solutions are reabsorbed very quickly by the airways, so the beneficial effects may not last very long. In the hopes of prolonging their effects, the drug amiloride could be used in combination to slow salt and water reabsorption from airways. Amiloride is a medication that has been given by mouth for high blood pressure for many years. It is possible that the combination of salt solutions and inhaled amiloride may significantly improve the clearance of secretions in CF, which would be expected to improve lung function in CF.
Interventions
- DRUG 7% NaCl
- DRUG Amiloride HCl
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2001-07 |
| Est. Completion | 2004-04 |
| Phase | Phase 2 |
What the finished NCT00274391 record still lists
NCT00274391 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 2 interventions - of which 7% NaCl is the first listed.
NCT00274391 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00274391 about?
NCT00274391 is a clinical study titled "Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis". The purpose of this research study is to determine whether the combination of inhaled amiloride and a concentrated salt solution is better than the salt solution itself for cystic fibrosis (CF) patients. In CF, airway secretions are thick and dehydrated. Many patients use inhaled salt solutions to h...
What is the current status of trial NCT00274391?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2001-07. Estimated completion is 2004-04.
What interventions are being tested in trial NCT00274391?
The interventions under investigation include: 7% NaCl (DRUG), Amiloride HCl (DRUG).
Who is sponsoring clinical trial NCT00274391?
This trial is sponsored by University of North Carolina, which has 14 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00274391's enrollment target sits among peer trials
24 1756th of 2000 higher than 217 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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